Mcam MGI Mouse Gene Detail - MGI:1933966 - melanoma cell adhesion molecule

Symbol

Mcam
Name

melanoma cell adhesion molecule
Synonyms

1-gicerin, CD146, Muc18, s-endo, s-gicerin

Feature Type

protein coding gene
IDs

MGI:1933966
NCBI Gene: 84004
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr9:44045958-44054024 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.68 cM
Mapping Data

2 experiments

SNPs within 2kb

213 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1933966	protein coding gene	Chr9:44045766-44054024 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034693	protein coding gene	Chr9:42598413-42605735 (+)
A/J	MGP_AJ_G0034674	protein coding gene	Chr9:41422271-41430531 (+)
AKR/J	MGP_AKRJ_G0034600	protein coding gene	Chr9:42282868-42292524 (+)
BALB/cJ	MGP_BALBcJ_G0034665	protein coding gene	Chr9:41165391-41173651 (+)
C3H/HeJ	MGP_C3HHeJ_G0034376	protein coding gene	Chr9:42736830-42744172 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035186	protein coding gene	Chr9:43871366-43881143 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032101	protein coding gene	Chr9:41013347-41020864 (+)
CAST/EiJ	MGP_CASTEiJ_G0033698	protein coding gene	Chr9:42575824-42583167 (+)
CBA/J	MGP_CBAJ_G0034348	protein coding gene	Chr9:45459548-45477820 (+)
DBA/2J	MGP_DBA2J_G0034507	protein coding gene	Chr9:41333396-41343052 (+)
FVB/NJ	MGP_FVBNJ_G0034448	protein coding gene	Chr9:40582829-40590171 (+)
LP/J	MGP_LPJ_G0034588	protein coding gene	Chr9:42901380-42908702 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034492	protein coding gene	Chr9:47327732-47335074 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035207	protein coding gene	Chr9:42175720-42183978 (+)
PWK/PhJ	MGP_PWKPhJ_G0033404	protein coding gene	Chr9:41199768-41207145 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033238	protein coding gene	Chr9:42475376-42483790 (+)
WSB/EiJ	MGP_WSBEiJ_G0033811	protein coding gene	Chr9:42213281-42220623 (+)

Human Ortholog

MCAM, melanoma cell adhesion molecule

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MCAM, melanoma cell adhesion molecule
Synonyms

CD146, HEMCAM, MelCAM, METCAM, MUC18
Links

HGNC:6934

NCBI Gene ID: 4162

neXtProt AC: NX_P43121

UniProt: P43121
Chr Location

11q23.3; chr11:119308529-119321521 (-) GRCh38

MGI Vertebrate Homology

Mcam stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MCAM
Gene Tree

Mcam

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Phenotype Summary

7 phenotypes from 3 alleles in 3 genetic backgrounds
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

5
Gene trapped

1
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in endothelial cells exhibit impaired VEGF-induced angiogenesis in Matrigel.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

880
Tissues

64
cDNA Data

8
Literature Summary

21

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mcam

ZFIN mcamb

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All Sequences

62
RefSeq

10
UniProt

4
CCDS

CCDS23097.1, CCDS90545.1

Ensembl

ENSMUSG00000032135 (Evidence)
NCBI Gene

84004

			Length	Strain/Species	Flank
genomic	84004	NCBI Gene Model \| MGI Sequence Detail	8067	C57BL/6J	± kb
transcript	NM_023061	RefSeq \| MGI Sequence Detail	2890	C57BL/6
polypeptide	Q8R2Y2	UniProt \| EBI \| MGI Sequence Detail	648	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001127 cell surface glycoprotein MUC18

(term hierarchy)
InterPro Domains

IPR013162 CD80-like, immunoglobulin C2-set

IPR051116 Cell Surface Receptors and Adhesion Molecules

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain
GlyGen

Q8R2Y2 4 sites, 3 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 10

cDNA 8

Primer pair 1

Other 1

Microarray probesets 3

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MGI:2143253

Summaries

All 84

Developmental Gene Expression 21

Gene Ontology 6

Phenotypes 30
Earliest

J:68338 Yang H, et al., Isolation and characterization of mouse MUC18 cDNA gene, and correlation of MUC18 expression in mouse melanoma cell lines with metastatic ability. Gene. 2001 Mar 7;265(1-2):133-45
Latest

J:347710 Sanketi BD, et al., Villus myofibroblasts are developmental and adult progenitors of mammalian gut lymphatic musculature. Dev Cell. 2024 Mar 19;

TSS for Mcam:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84624	Chr9:44045503-44045551 (+)	-431 bp
Tssr84625	Chr9:44045950-44045967 (+)	1 bp
Tssr84626	Chr9:44051887-44051906 (+)	5,939 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24