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Nucks1 Gene Detail
Summary
  • Symbol
    Nucks1
  • Name
    nuclear casein kinase and cyclin-dependent kinase substrate 1
  • Synonyms
    2700010L10Rik, 8430423A01Rik, Nucks
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934811
    NCBI Gene: 98415
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:131838272-131864059 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 57.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    530 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934811
 protein coding gene Chr1:131838196-131864059 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016462
 protein coding gene Chr1:135354939-135384910 (+)
A/J MGP_AJ_G0016445
 protein coding gene Chr1:130350821-130378357 (+)
AKR/J MGP_AKRJ_G0016410
 protein coding gene Chr1:134176311-134204094 (+)
BALB/cJ MGP_BALBcJ_G0016405
 protein coding gene Chr1:130669579-130697517 (+)
C3H/HeJ MGP_C3HHeJ_G0016231
 protein coding gene Chr1:134323934-134351587 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016866
 protein coding gene Chr1:140400197-140428880 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014577
 protein coding gene Chr1:123500738-123524250 (+)
CAST/EiJ MGP_CASTEiJ_G0015811
 protein coding gene Chr1:133316379-133350319 (+)
CBA/J MGP_CBAJ_G0016203
 protein coding gene Chr1:145175726-145204660 (+)
DBA/2J MGP_DBA2J_G0016310
 protein coding gene Chr1:129313439-129341411 (+)
FVB/NJ MGP_FVBNJ_G0016309
 protein coding gene Chr1:127937335-127963944 (+)
LP/J MGP_LPJ_G0016381
 protein coding gene Chr1:136672586-136702864 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016334
 protein coding gene Chr1:150949071-150993249 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016902
 protein coding gene Chr1:133936742-133962483 (+)
PWK/PhJ MGP_PWKPhJ_G0015597
 protein coding gene Chr1:128280813-128301598 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015384
 protein coding gene Chr1:132884912-132910897 (+)
WSB/EiJ MGP_WSBEiJ_G0015873
 protein coding gene Chr1:133924556-133950203 (+)



Homology
more
  • Human Ortholog
    NUCKS1, nuclear casein kinase and cyclin dependent kinase substrate 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUCKS1, nuclear casein kinase and cyclin dependent kinase substrate 1
  • Synonyms
    JC7, NUCKS
  • Links
    NCBI Gene ID: 64710
    neXtProt AC: NX_Q9H1E3
    UniProt: Q9H1E3

  • Chr Location
    1q32.1; chr1:205712822-205750182 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO leads to increased body fat, reduced energy expenditure, hypoactivity, reduced glucose tolerance, increased insulin levels and insulin resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    13
  • cDNA Data
    10
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026434 Ensembl Gene Model | MGI Sequence Detail 25788 C57BL/6J ±  kb
    transcript ENSMUST00000062264 Ensembl | MGI Sequence Detail 5998 Not Applicable  
    polypeptide ENSMUSP00000062576 Ensembl | MGI Sequence Detail 234 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011481 nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
      (term hierarchy)
    • InterPro Domains
      IPR052003 Homologous Recombination DNA-Binding Protein
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 1
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1919821, MGI:2138310, MGI:2138671
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory