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Amn Gene Detail
Summary
  • Symbol
    Amn
  • Name
    amnionless
  • Synonyms
    5033428N14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1934943
    NCBI Gene: 93835
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:111237530-111242860 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 60.94 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    261 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1934943
 protein coding gene Chr12:111237529-111242860 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020129
 protein coding gene Chr12:113642798-113649491 (+)
A/J MGP_AJ_G0020085
 protein coding gene Chr12:109283753-109289049 (+)
AKR/J MGP_AKRJ_G0020060
 protein coding gene Chr12:112412834-112418148 (+)
BALB/cJ MGP_BALBcJ_G0020070
 protein coding gene Chr12:109699053-109704368 (+)
C3H/HeJ MGP_C3HHeJ_G0019872
 protein coding gene Chr12:112917621-112922922 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020515
 protein coding gene Chr12:117172136-117177704 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018128
 protein coding gene Chr12:105727040-105732426 (+)
CAST/EiJ MGP_CASTEiJ_G0019413
 protein coding gene Chr12:107761560-107766886 (+)
CBA/J MGP_CBAJ_G0019839
 protein coding gene Chr12:121658301-121663613 (+)
DBA/2J MGP_DBA2J_G0019956
 protein coding gene Chr12:108766631-108771941 (+)
FVB/NJ MGP_FVBNJ_G0019941
 protein coding gene Chr12:107559192-107564742 (+)
LP/J MGP_LPJ_G0020031
 protein coding gene Chr12:113443241-113448553 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019979
 protein coding gene Chr12:124780453-124785767 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020544
 protein coding gene Chr12:111916299-111921781 (+)
PWK/PhJ MGP_PWKPhJ_G0019174
 protein coding gene Chr12:103398143-103403682 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018977
 protein coding gene Chr12:106080841-106086169 (+)
WSB/EiJ MGP_WSBEiJ_G0019472
 protein coding gene Chr12:112847037-112852395 (+)



Homology
more
  • Human Ortholog
    AMN, amnion associated transmembrane protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMN, amnion associated transmembrane protein
  • Synonyms
    amnionless, IGS2, PRO1028
  • Links
    NCBI Gene ID: 81693
    neXtProt AC: NX_Q9BXJ7
    UniProt: Q9BXJ7

  • Chr Location
    14q32.32; chr14:102922663-102933596 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AMN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 4 genetic backgrounds
    8 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic growth arrest between the mid and late streak stages of gastrulation and abnormal ectoderm formation, followed by death. Generation of middle primitive streak derivatives is impaired, leading to absence of mesoderm and somites.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    8
  • cDNA Data
    34
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93835 NCBI Gene Model | MGI Sequence Detail 5331 C57BL/6J ±  kb
    transcript NM_033603 RefSeq | MGI Sequence Detail 1700 ZRU/MplStud  
    polypeptide Q99JB7 UniProt | EBI | MGI Sequence Detail 458 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 4
      cDNA 37
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914845, MGI:2144974
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 11
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:319880 Coffey JW, et al., Studies on the Interaction of Vitamin B12: Intrinsic Factor and Receptors. Arch Biochem Biophys. 1965 Apr;110:117-123
    • Latest
      J:338444 Liang S, et al., Generation and characterization of an inducible renal proximal tubule-specific CreERT2 mouse. Front Cell Dev Biol. 2023;11:1171637
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory