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Slc1a4 Gene Detail
Summary
  • Symbol
    Slc1a4
  • Name
    solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
  • Synonyms
    ASCT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135601
    NCBI Gene: 55963
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:20252180-20282713 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 12.97 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1057 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135601
 protein coding gene Chr11:20252180-20282713 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018066
 protein coding gene Chr11:17819333-17851105 (-)
A/J MGP_AJ_G0018039
 protein coding gene Chr11:17226221-17258991 (-)
AKR/J MGP_AKRJ_G0018003
 protein coding gene Chr11:17835357-17867216 (-)
BALB/cJ MGP_BALBcJ_G0018007
 protein coding gene Chr11:17343992-17374083 (-)
C3H/HeJ MGP_C3HHeJ_G0017821
 protein coding gene Chr11:17728756-17758017 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018459
 protein coding gene Chr11:18630164-18663868 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016117
 protein coding gene Chr11:16217542-16246773 (-)
CAST/EiJ MGP_CASTEiJ_G0017382
 protein coding gene Chr11:17688674-17720880 (-)
CBA/J MGP_CBAJ_G0017795
 protein coding gene Chr11:19440764-19477320 (-)
DBA/2J MGP_DBA2J_G0017905
 protein coding gene Chr11:17173363-17200657 (-)
FVB/NJ MGP_FVBNJ_G0017897
 protein coding gene Chr11:16913770-16943265 (-)
LP/J MGP_LPJ_G0017976
 protein coding gene Chr11:17993137-18025540 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017923
 protein coding gene Chr11:19892107-19923991 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018500
 protein coding gene Chr11:17920096-17951706 (-)
PWK/PhJ MGP_PWKPhJ_G0017162
 protein coding gene Chr11:17182700-17212263 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016960
 protein coding gene Chr11:17642462-17675036 (-)
WSB/EiJ MGP_WSBEiJ_G0017436
 protein coding gene Chr11:17578488-17608935 (-)



Homology
more
  • Human Ortholog
    SLC1A4, solute carrier family 1 member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC1A4, solute carrier family 1 member 4
  • Synonyms
    ASCT1, SATT, SPATCCM
  • Links
    NCBI Gene ID: 6509
    neXtProt AC: NX_P43007
    UniProt: P43007

  • Chr Location
    2p14; chr2:64988477-65023865 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc1a4 mouse models; 1 with human SLC1A4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    819
  • Tissues
    26
  • cDNA Data
    90
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 55963 NCBI Gene Model | MGI Sequence Detail 30534 C57BL/6J ±  kb
    transcript NM_018861 RefSeq | MGI Sequence Detail 3901 C57BL/6  
    polypeptide O35874 UniProt | EBI | MGI Sequence Detail 532 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000014975 neutral amino acid transporter A
      (term hierarchy)
    • InterPro Domains
      IPR050746 Dicarboxylate/Amino Acid:Cation Symporter
      IPR001991 Sodium:dicarboxylate symporter
      IPR018107 Sodium:dicarboxylate symporter, conserved site
      IPR036458 Sodium:dicarboxylate symporter superfamily
    • GlyGen
      O35874 3 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 93
      cDNA 90
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144477
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory