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Lin7a Gene Detail
Summary
  • Symbol
    Lin7a
  • Name
    lin-7 homolog A, crumbs cell polarity complex component
  • Synonyms
    LIN-7A, MALS-1, TIP-33, Veli
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135609
    NCBI Gene: 108030
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:107107547-107257335 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 55.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4412 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135609
 protein coding gene Chr10:107107410-107261007 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017707
 protein coding gene Chr10:109450394-109606717 (+)
A/J MGP_AJ_G0017684
 protein coding gene Chr10:105362060-105511051 (+)
AKR/J MGP_AKRJ_G0017646
 protein coding gene Chr10:108429728-108575971 (+)
BALB/cJ MGP_BALBcJ_G0017648
 protein coding gene Chr10:105749362-105900493 (+)
C3H/HeJ MGP_C3HHeJ_G0017473
 protein coding gene Chr10:108517822-108672619 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018105
 protein coding gene Chr10:113257353-113416687 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0017034
 protein coding gene Chr10:108614966-108766876 (+)
CBA/J MGP_CBAJ_G0017442
 protein coding gene Chr10:117661072-117826666 (+)
DBA/2J MGP_DBA2J_G0017547
 protein coding gene Chr10:104498403-104649692 (+)
FVB/NJ MGP_FVBNJ_G0017541
 protein coding gene Chr10:103499844-103648620 (+)
LP/J MGP_LPJ_G0017621
 protein coding gene Chr10:110080097-110235443 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017571
 protein coding gene Chr10:120175926-120343897 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018143
 protein coding gene Chr10:108404580-108564909 (+)
PWK/PhJ MGP_PWKPhJ_G0016816
 protein coding gene Chr10:104553555-104700950 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016606
 protein coding gene Chr10:107161481-107304617 (+)
WSB/EiJ MGP_WSBEiJ_G0017094
 protein coding gene Chr10:108525108-108683178 (+)



Homology
more
  • Human Ortholog
    LIN7A, lin-7 homolog A, crumbs cell polarity complex component
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIN7A, lin-7 homolog A, crumbs cell polarity complex component
  • Synonyms
    LIN7, LIN-7A, MALS-1, MALS1, TIP-33, VELI1
  • Links
    NCBI Gene ID: 8825
    neXtProt AC: NX_O14910
    UniProt: O14910

  • Chr Location
    12q21.31; chr12:80792520-80937934 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    11 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Targeted
    1
  • Genomic Mutations
    1 involving Lin7a
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    23 strains or lines available
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    886
  • Tissues
    31
  • cDNA Data
    30
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019906 Ensembl Gene Model | MGI Sequence Detail 149789 C57BL/6J ±  kb
transcript ENSMUST00000020057 Ensembl | MGI Sequence Detail 2363 Not Applicable  
polypeptide ENSMUSP00000020057 Ensembl | MGI Sequence Detail 233 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 30
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2143687
References
more
  • Summaries
    All 55
    Developmental Gene Expression 8
    Gene Ontology 14
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:304253 Jones MR, et al., A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Front Genet. 2018;9:746
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory