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Cox4i2 Gene Detail
Summary
  • Symbol
    Cox4i2
  • Name
    cytochrome c oxidase subunit 4I2
  • Synonyms
    Cox4b, Cox IV-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135755
    NCBI Gene: 84682
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152596093-152606957 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.41 cM, cytoband H2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    391 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135755
 protein coding gene Chr2:152596093-152606957 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026677
 protein coding gene Chr2:157333330-157344228 (+)
A/J MGP_AJ_G0026643
 protein coding gene Chr2:151049652-151060545 (+)
AKR/J MGP_AKRJ_G0026613
 protein coding gene Chr2:155451839-155463964 (+)
BALB/cJ MGP_BALBcJ_G0026652
 protein coding gene Chr2:151358982-151369833 (+)
C3H/HeJ MGP_C3HHeJ_G0026395
 protein coding gene Chr2:155838523-155850164 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027101
 protein coding gene Chr2:161896848-161907883 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024472
 protein coding gene Chr2:144640190-144651926 (+)
CAST/EiJ MGP_CASTEiJ_G0025856
 protein coding gene Chr2:156091137-156103301 (+)
CBA/J MGP_CBAJ_G0026373
 protein coding gene Chr2:167857586-167868442 (+)
DBA/2J MGP_DBA2J_G0026509
 protein coding gene Chr2:150262184-150272988 (+)
FVB/NJ MGP_FVBNJ_G0026475
 protein coding gene Chr2:148719464-148730257 (+)
LP/J MGP_LPJ_G0026613
 protein coding gene Chr2:157488947-157499818 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026496
 protein coding gene Chr2:171937592-171948479 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027157
 protein coding gene Chr2:155354542-155365402 (+)
PWK/PhJ MGP_PWKPhJ_G0025590
 protein coding gene Chr2:149782717-149794242 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025393
 protein coding gene Chr2:154192082-154202963 (+)
WSB/EiJ MGP_WSBEiJ_G0025926
 protein coding gene Chr2:156259565-156270384 (+)



Homology
more
  • Human Ortholog
    COX4I2, cytochrome c oxidase subunit 4I2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX4I2, cytochrome c oxidase subunit 4I2
  • Synonyms
    COX4, COX4-2, COX4B, COX4L2, COXIV-2, dJ857M17.2
  • Links
    NCBI Gene ID: 84701
    neXtProt AC: NX_Q96KJ9
    UniProt: Q96KJ9

  • Chr Location
    20q11.21; chr20:31637912-31645006 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display lung inflammation and decreased airway responsiveness. Females show decreased lean body mass and improved glucose tolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    98
  • cDNA Data
    10
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 84682 NCBI Gene Model | MGI Sequence Detail 10865 C57BL/6J ±  kb
    transcript NM_053091 RefSeq | MGI Sequence Detail 727 C57BL/6  
    polypeptide Q91W29 UniProt | EBI | MGI Sequence Detail 172 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005777 cytochrome c oxidase subunit 4 isoform 2, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR013288 Cytochrome c oxidase subunit IV
      IPR004203 Cytochrome c oxidase subunit IV family
      IPR036639 Cytochrome c oxidase subunit IV superfamily
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 10
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:304 STEIN KF, et al., Morphology and behavior of Waltzertype mice. J Morphol. 1960 Mar;106:197-203
    • Latest
      J:344566 Zanini F, et al., Hyperoxia prevents the dynamic neonatal increases in lung mesenchymal cell diversity. Sci Rep. 2024 Jan 23;14(1):2033
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory