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Mpv17l Gene Detail
Summary
  • Symbol
    Mpv17l
  • Name
    Mpv17 transgene, kidney disease mutant-like
  • Synonyms
    M-LP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135951
    NCBI Gene: 93734
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:13721025-13767483 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 9.64 cM, cytoband B1-B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    911 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135951
 protein coding gene Chr16:13721025-13767483 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022538
 protein coding gene Chr16:10926380-10971995 (+)
A/J MGP_AJ_G0022500
 protein coding gene Chr16:10314216-10354609 (+)
AKR/J MGP_AKRJ_G0022476
 protein coding gene Chr16:10763147-10808794 (+)
BALB/cJ MGP_BALBcJ_G0022504
 protein coding gene Chr16:10480660-10534880 (+)
C3H/HeJ MGP_C3HHeJ_G0022271
 protein coding gene Chr16:10855592-10904331 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022953
 protein coding gene Chr16:11077561-11119222 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020473
 protein coding gene Chr16:10401802-10438558 (+)
CAST/EiJ MGP_CASTEiJ_G0021798
 protein coding gene Chr16:10872835-10931698 (+)
CBA/J MGP_CBAJ_G0022240
 protein coding gene Chr16:11613333-11656630 (+)
DBA/2J MGP_DBA2J_G0022371
 protein coding gene Chr16:10303944-10353521 (+)
FVB/NJ MGP_FVBNJ_G0022347
 protein coding gene Chr16:10287441-10336630 (+)
LP/J MGP_LPJ_G0022439
 protein coding gene Chr16:10820382-10860459 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022369
 protein coding gene Chr16:11230967-11291708 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022966
 protein coding gene Chr16:10736291-10776492 (+)
PWK/PhJ MGP_PWKPhJ_G0021540
 protein coding gene Chr16:10568637-10610606 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021368
 protein coding gene Chr16:10725982-10762818 (+)
WSB/EiJ MGP_WSBEiJ_G0021846
 protein coding gene Chr16:10759189-10807704 (+)



Homology
more
  • Human Ortholog
    MPV17L, MPV17 mitochondrial inner membrane protein like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPV17L, MPV17 mitochondrial inner membrane protein like
  • Synonyms
    M-LPH, M-LPH1, MLPH1, M-LPH2, MLPH2, MPV17L1
  • Links
    NCBI Gene ID: 255027
    neXtProt AC: NX_Q2QL34
    UniProt: Q2QL34

  • Chr Location
    16p13.11; chr16:15395754-15413271 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit enlarged pancreatic islets and improved glucose tolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    56
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93734 NCBI Gene Model | MGI Sequence Detail 46459 C57BL/6J ±  kb
    transcript NM_001289567 RefSeq | MGI Sequence Detail 3382 C57BL/6  
    polypeptide Q99MS3 UniProt | EBI | MGI Sequence Detail 194 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 57

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:69263 Iida R, et al., Cloning, mapping, genomic organization, and expression of mouse M-LP, a new member of the peroxisomal membrane protein Mpv17 domain family. Biochem Biophys Res Commun. 2001 May 4;283(2):292-6
    • Latest
      J:319850 Iida R, et al., Deficiency of M-LP/Mpv17L leads to development of beta-cell hyperplasia and improved glucose tolerance via activation of the Wnt and TGF-beta pathways. Biochim Biophys Acta Mol Basis Dis. 2022 Mar 1;1868(3):166318
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory