About   Help   FAQ
Glce Gene Detail
Summary
  • Symbol
    Glce
  • Name
    glucuronyl C5-epimerase
  • Synonyms
    1110017N23Rik, C130034A12Rik, heparan sulfate-glucuronic acid C5-epimerase, Hsepi
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136405
    NCBI Gene: 93683
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:61964526-62029891 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 33.56 cM, cytoband C-D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136405
 protein coding gene Chr9:61964526-62029937 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034918
 protein coding gene Chr9:61571833-61642689 (-)
A/J MGP_AJ_G0034898
 protein coding gene Chr9:59554357-59620431 (-)
AKR/J MGP_AKRJ_G0034828
 protein coding gene Chr9:60927546-60994895 (-)
BALB/cJ MGP_BALBcJ_G0034891
 protein coding gene Chr9:59275529-59343220 (-)
C3H/HeJ MGP_C3HHeJ_G0034601
 protein coding gene Chr9:61429483-61499540 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035410
 protein coding gene Chr9:63247620-63314671 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032321
 protein coding gene Chr9:59232281-59293144 (-)
CAST/EiJ MGP_CASTEiJ_G0033922
 protein coding gene Chr9:61554476-61621754 (-)
CBA/J MGP_CBAJ_G0034572
 protein coding gene Chr9:65426841-65491805 (-)
DBA/2J MGP_DBA2J_G0034731
 protein coding gene Chr9:59355184-59421382 (-)
FVB/NJ MGP_FVBNJ_G0034673
 protein coding gene Chr9:58639485-58704708 (-)
LP/J MGP_LPJ_G0034814
 protein coding gene Chr9:61852229-61916981 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034716
 protein coding gene Chr9:66834545-66905543 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035432
 protein coding gene Chr9:60997047-61065020 (-)
PWK/PhJ MGP_PWKPhJ_G0033626
 protein coding gene Chr9:59469035-59535563 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033459
 protein coding gene Chr9:61289169-61359259 (-)
WSB/EiJ MGP_WSBEiJ_G0034035
 protein coding gene Chr9:60913093-60979703 (-)



Homology
more
  • Human Ortholog
    GLCE, glucuronic acid epimerase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLCE, glucuronic acid epimerase
  • Synonyms
    HSEPI
  • Links
    NCBI Gene ID: 26035
    neXtProt AC: NX_O94923
    UniProt: O94923

  • Chr Location
    15q23; chr15:69160584-69272217 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GLCE associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die immediately after birth showing severe developmental defects including renal agenesis, lung abnormalities, and skeletal malformations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    127
  • cDNA Data
    13
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93683 NCBI Gene Model | MGI Sequence Detail 65366 C57BL/6J ±  kb
    transcript NR_160774 RefSeq | MGI Sequence Detail 5733 C57BL/6  
    polypeptide Q9EPS3 UniProt | EBI | MGI Sequence Detail 618 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1922030, MGI:2143115, MGI:2443854
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 9
      Gene Ontology 11
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory