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Tmem121b Gene Detail
Summary
  • Symbol
    Tmem121b
  • Name
    transmembrane protein 121B
  • Synonyms
    Cecr6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136977
    NCBI Gene: 94047
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:120465900-120470768 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 56.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136977
 protein coding gene Chr6:120465900-120470907 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031205
 protein coding gene Chr6:123381668-123386536 (-)
A/J MGP_AJ_G0031174
 protein coding gene Chr6:118639444-118644312 (-)
AKR/J MGP_AKRJ_G0031105
 protein coding gene Chr6:121841785-121846653 (-)
BALB/cJ MGP_BALBcJ_G0031185
 protein coding gene Chr6:118402436-118407304 (-)
C3H/HeJ MGP_C3HHeJ_G0030524
 protein coding gene Chr6:62466907-62471775 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031643
 protein coding gene Chr6:126530705-126535573 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028803
 protein coding gene Chr6:115541462-115546274 (-)
CAST/EiJ MGP_CASTEiJ_G0030292
 protein coding gene Chr6:122281410-122286235 (-)
CBA/J MGP_CBAJ_G0030868
 protein coding gene Chr6:131561131-131565999 (-)
DBA/2J MGP_DBA2J_G0031024
 protein coding gene Chr6:117523872-117528740 (-)
FVB/NJ MGP_FVBNJ_G0030976
 protein coding gene Chr6:116653534-116658798 (-)
LP/J MGP_LPJ_G0031103
 protein coding gene Chr6:123371444-123376312 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031010
 protein coding gene Chr6:135545066-135549934 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031672
 protein coding gene Chr6:121861490-121866358 (-)
PWK/PhJ MGP_PWKPhJ_G0030007
 protein coding gene Chr6:116564232-116569024 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029836
 protein coding gene Chr6:120597476-120602306 (-)
WSB/EiJ MGP_WSBEiJ_G0030375
 protein coding gene Chr6:122155111-122159979 (-)



Homology
more
  • Human Ortholog
    TMEM121B, transmembrane protein 121B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM121B, transmembrane protein 121B
  • Synonyms
    CECR6
  • Links
    NCBI Gene ID: 27439
    neXtProt AC: NX_Q9BXQ6
    UniProt: Q9BXQ6

  • Chr Location
    22q11.1; chr22:17116297-17121367 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000094626 Ensembl Gene Model | MGI Sequence Detail 4869 C57BL/6J ±  kb
    transcript ENSMUST00000178687 Ensembl | MGI Sequence Detail 4869 Not Applicable  
    polypeptide ENSMUSP00000135924 Ensembl | MGI Sequence Detail 572 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141636, MGI:5908445
    References
    more
    • Summaries
      All 25
      Phenotypes 4
    • Earliest
      J:69774 Bruce SR, et al., Multiple features contribute to efficient constitutive splicing of an unusually large exon. Nucleic Acids Res. 2001 Jun 1;29(11):2292-302
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory