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Arid4b Gene Detail
Summary
  • Symbol
    Arid4b
  • Name
    AT-rich interaction domain 4B
  • Synonyms
    6330417L24Rik, 6720480E17Rik, BRCAA1, RBBP1L1, Rbp1l1, SAP180
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137512
    NCBI Gene: 94246
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:14238334-14374188 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 5.29 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2768 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137512
 protein coding gene Chr13:14237817-14374188 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020242
 protein coding gene Chr13:11032372-11175592 (+)
A/J MGP_AJ_G0020200
 protein coding gene Chr13:10956136-11095891 (+)
AKR/J MGP_AKRJ_G0020174
 protein coding gene Chr13:11074843-11222710 (+)
BALB/cJ MGP_BALBcJ_G0020186
 protein coding gene Chr13:10937660-11079460 (+)
C3H/HeJ MGP_C3HHeJ_G0019990
 protein coding gene Chr13:11235574-11384825 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020630
 protein coding gene Chr13:11605851-11764357 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018236
 protein coding gene Chr13:9687381-9831315 (+)
CAST/EiJ MGP_CASTEiJ_G0019523
 protein coding gene Chr13:10893928-11044644 (+)
CBA/J MGP_CBAJ_G0019954
 protein coding gene Chr13:11964471-12127005 (+)
DBA/2J MGP_DBA2J_G0020073
 protein coding gene Chr13:10606308-10739330 (+)
FVB/NJ MGP_FVBNJ_G0020054
 protein coding gene Chr13:10365920-10508112 (+)
LP/J MGP_LPJ_G0020143
 protein coding gene Chr13:11217743-11386736 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020091
 protein coding gene Chr13:12065078-12236871 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020657
 protein coding gene Chr13:10878677-11027118 (+)
PWK/PhJ MGP_PWKPhJ_G0019287
 protein coding gene Chr13:10681489-10837950 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019094
 protein coding gene Chr13:10045692-10218394 (+)
WSB/EiJ MGP_WSBEiJ_G0019585
 protein coding gene Chr13:10900940-11050424 (+)



Homology
more
  • Human Ortholog
    ARID4B, AT-rich interaction domain 4B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARID4B, AT-rich interaction domain 4B
  • Synonyms
    BCAA, BRCAA1, RBBP1L1, RBP1L1, SAP180
  • Links
    NCBI Gene ID: 51742
    neXtProt AC: NX_Q4LE39
    UniProt: Q4LE39

  • Chr Location
    1q42.3; chr1:235131634-235328219 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    33 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die pre-implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    5
  • cDNA Data
    104
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 94246 NCBI Gene Model | MGI Sequence Detail 135855 C57BL/6J ±  kb
    transcript NM_194262 RefSeq | MGI Sequence Detail 6113 ZRU/MplStud  
    polypeptide A2CG63 UniProt | EBI | MGI Sequence Detail 1314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 4
      cDNA 104
      Primer pair 2

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1917988, MGI:1924943
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:320044 Zhang Y, et al., SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell. 1998 Jun;1(7):1021-31
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory