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Twsg1 Gene Detail
Summary
  • Symbol
    Twsg1
  • Name
    twisted gastrulation BMP signaling modulator 1
  • Synonyms
    1810013J15Rik, 9030422N06Rik, D17Ertd403e, Tsg
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137520
    NCBI Gene: 65960
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:66230060-66258198 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 35.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    957 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137520
 protein coding gene Chr17:66228967-66258221 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023982
 protein coding gene Chr17:68086165-68114856 (-)
A/J MGP_AJ_G0023940
 protein coding gene Chr17:66047946-66076790 (-)
AKR/J MGP_AKRJ_G0023909
 protein coding gene Chr17:66978170-67006145 (-)
BALB/cJ MGP_BALBcJ_G0023941
 protein coding gene Chr17:66000028-66031185 (-)
C3H/HeJ MGP_C3HHeJ_G0023705
 protein coding gene Chr17:67857449-67888652 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024387
 protein coding gene Chr17:70707643-70737519 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021833
 protein coding gene Chr17:62071959-62106274 (-)
CAST/EiJ MGP_CASTEiJ_G0023187
 protein coding gene Chr17:68194777-68230634 (-)
CBA/J MGP_CBAJ_G0023681
 protein coding gene Chr17:73478290-73514097 (-)
DBA/2J MGP_DBA2J_G0023809
 protein coding gene Chr17:64794970-64823627 (-)
FVB/NJ MGP_FVBNJ_G0023775
 protein coding gene Chr17:64277629-64306772 (-)
LP/J MGP_LPJ_G0023891
 protein coding gene Chr17:68797636-68826774 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023803
 protein coding gene Chr17:73577431-73609095 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024431
 protein coding gene Chr17:67429186-67457882 (-)
PWK/PhJ MGP_PWKPhJ_G0022933
 protein coding gene Chr17:64064768-64100401 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022744
 protein coding gene Chr17:64107163-64142195 (-)
WSB/EiJ MGP_WSBEiJ_G0023253
 protein coding gene Chr17:68134563-68166655 (-)



Homology
more
  • Human Ortholog
    TWSG1, twisted gastrulation BMP signaling modulator 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TWSG1, twisted gastrulation BMP signaling modulator 1
  • Synonyms
    TSG
  • Links
    NCBI Gene ID: 57045
    neXtProt AC: NX_Q9GZX9
    UniProt: Q9GZX9

  • Chr Location
    18p11.22
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    94 phenotypes from 6 alleles in 9 genetic backgrounds
    31 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice appear healthy at birth, but more than half of the progeny fail to thrive and exhibit dwarfism with delayed ossification and immune system. These defects result in premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    907
  • Tissues
    117
  • cDNA Data
    141
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65960 NCBI Gene Model | MGI Sequence Detail 28139 C57BL/6J ±  kb
    transcript NM_023053 RefSeq | MGI Sequence Detail 4032 ZRU/MplStud  
    polypeptide Q9EP52 UniProt | EBI | MGI Sequence Detail 222 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 150
      cDNA 143
      Primer pair 6
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1261766, MGI:1916293, MGI:1918789, MGI:2147085
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 20
      Gene Ontology 10
      Phenotypes 23
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:262487 Murgai A, et al., Cooperation of BMP and IHH signaling in interdigital cell fate determination. PLoS One. 2018;13(5):e0197535
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory