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Kmo Gene Detail
Summary
  • Symbol
    Kmo
  • Name
    kynurenine 3-monooxygenase
  • Synonyms
    kynurenine 3-hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138151
    NCBI Gene: 98256
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:175459759-175488419 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 81.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138151
 protein coding gene Chr1:175447947-175489682 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016837
 protein coding gene Chr1:181720335-181763560 (+)
A/J MGP_AJ_G0016816
 protein coding gene Chr1:174390667-174439754 (+)
AKR/J MGP_AKRJ_G0016782
 protein coding gene Chr1:179607810-179652384 (+)
BALB/cJ MGP_BALBcJ_G0016774
 protein coding gene Chr1:174931547-174973195 (+)
C3H/HeJ MGP_C3HHeJ_G0016599
 protein coding gene Chr1:180218505-180261357 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017239
 protein coding gene Chr1:187717090-187763763 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014944
 protein coding gene Chr1:165710723-165753442 (+)
CAST/EiJ MGP_CASTEiJ_G0016180
 protein coding gene Chr1:179581237-179628767 (+)
CBA/J MGP_CBAJ_G0016573
 protein coding gene Chr1:194576519-194617816 (+)
DBA/2J MGP_DBA2J_G0016678
 protein coding gene Chr1:173251525-173293212 (+)
FVB/NJ MGP_FVBNJ_G0016675
 protein coding gene Chr1:171376699-171418545 (+)
LP/J MGP_LPJ_G0016754
 protein coding gene Chr1:182915344-182957148 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016707
 protein coding gene Chr1:201815686-201858785 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017274
 protein coding gene Chr1:179381716-179425362 (+)
PWK/PhJ MGP_PWKPhJ_G0015967
 protein coding gene Chr1:172340370-172382684 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015744
 protein coding gene Chr1:178419380-178460997 (+)
WSB/EiJ MGP_WSBEiJ_G0016242
 protein coding gene Chr1:179578989-179622569 (+)



Homology
more
  • Human Ortholog
    KMO, kynurenine 3-monooxygenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KMO, kynurenine 3-monooxygenase
  • Synonyms
    dJ317G22.1
  • Links
    NCBI Gene ID: 8564
    neXtProt AC: NX_O15229
    UniProt: O15229

  • Chr Location
    1q43; chr1:241532134-241595642 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele lack kynurenine 3-monooxygenase activity and altered levels of several tryptophan metabolites. Mice homozygous for another null allele exhibit increased LPS-induced depressive behaviors and altered kynurenine metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    98
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 98256 NCBI Gene Model | MGI Sequence Detail 28661 C57BL/6J ±  kb
    transcript NM_133809 RefSeq | MGI Sequence Detail 2512 FVB/N  
    polypeptide Q91WN4 UniProt | EBI | MGI Sequence Detail 479 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 25
    • Earliest
      J:86816 Mootha VK, et al., Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell. 2003 Nov 26;115(5):629-40
    • Latest
      J:339010 Hayes AJ, et al., Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis. Cell Rep. 2023 Jul 19;42(8):112763
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory