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D2hgdh Gene Detail
Summary
  • Symbol
    D2hgdh
  • Name
    D-2-hydroxyglutarate dehydrogenase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138209
    NCBI Gene: 98314
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:93752631-93780070 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 47.36 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    489 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138209
 protein coding gene Chr1:93752531-93781583 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016351
 protein coding gene Chr1:95472833-95474381 (+)
A/J MGP_AJ_G0016332
 protein coding gene Chr1:92056488-92081762 (+)
AKR/J MGP_AKRJ_G0016293
 protein coding gene Chr1:94769696-94802990 (+)
BALB/cJ MGP_BALBcJ_G0016288
 protein coding gene Chr1:92237541-92272621 (+)
C3H/HeJ MGP_C3HHeJ_G0016117
 protein coding gene Chr1:95025984-95216356 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016747
 protein coding gene Chr1:99099991-99238465 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014465
 protein coding gene Chr1:86297601-86320363 (+)
CAST/EiJ MGP_CASTEiJ_G0015700
 protein coding gene Chr1:94357244-94515380 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0016267
 protein coding gene Chr1:96654686-96697620 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016220
 protein coding gene Chr1:105396488-105593950 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016786
 protein coding gene Chr1:94802381-94947262 (+)
PWK/PhJ MGP_PWKPhJ_G0015485
 protein coding gene Chr1:90687059-90700026 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015269
 protein coding gene Chr1:93739209-93762498 (+)
WSB/EiJ MGP_WSBEiJ_G0015760
 protein coding gene Chr1:94617452-94642997 (+)



Homology
more
  • Human Ortholog
    D2HGDH, D-2-hydroxyglutarate dehydrogenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    D2HGDH, D-2-hydroxyglutarate dehydrogenase
  • Synonyms
    D2HGD
  • Links
    NCBI Gene ID: 728294
    neXtProt AC: NX_Q8N465
    UniProt: Q8N465

  • Chr Location
    2q37.3; chr2:241734602-241768816 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human D2HGDH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    47
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000073609 Ensembl Gene Model | MGI Sequence Detail 27440 C57BL/6J ±  kb
transcript ENSMUST00000112881 Ensembl | MGI Sequence Detail 3459 Not Applicable  
polypeptide ENSMUSP00000108502 Ensembl | MGI Sequence Detail 557 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006254 D-2-hydroxyglutarate dehydrogenase, mitochondrial
    (term hierarchy)
  • EC
    1.1.99.39
  • InterPro Domains
    IPR016166 FAD-binding domain, PCMH-type
    IPR051264 FAD-binding Oxidoreductase/Transferase Type 4
    IPR004113 FAD-binding oxidoreductase/transferase, type 4, C-terminal
    IPR036318 FAD-binding, type PCMH-like superfamily
    IPR016167 FAD-binding, type PCMH, subdomain 1
    IPR016169 FAD-binding, type PCMH, subdomain 2
    IPR016164 FAD-linked oxidase-like, C-terminal
    IPR006094 FAD linked oxidase, N-terminal
    IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2
Molecular
Reagents
less
  • All nucleic 47
    cDNA 47

    Microarray probesets 4
Other
Accession IDs
less
MGI:2138084, MGI:2138085
References
more
  • Summaries
    All 37
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:333441 Liu Y, et al., D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase. Cell Rep. 2023 Jan 31;42(2):112067
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory