About   Help   FAQ
Smap1 Gene Detail
Summary
  • Symbol
    Smap1
  • Name
    small ArfGAP 1
  • Synonyms
    1700056O10Rik, 4921514B13Rik, 4921525H11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138261
    NCBI Gene: 98366
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:23883927-23961398 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 9.79 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1965 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138261
 protein coding gene Chr1:23883925-23961462 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015886
 protein coding gene Chr1:21673676-21745613 (-)
A/J MGP_AJ_G0015867
 protein coding gene Chr1:21243551-21314912 (-)
AKR/J MGP_AKRJ_G0015824
 protein coding gene Chr1:21458603-21540862 (-)
BALB/cJ MGP_BALBcJ_G0015823
 protein coding gene Chr1:20982181-21061585 (-)
C3H/HeJ MGP_C3HHeJ_G0015657
 protein coding gene Chr1:21465093-21542398 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016277
 protein coding gene Chr1:22640479-22714501 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013996
 protein coding gene Chr1:19322274-19398779 (-)
CAST/EiJ MGP_CASTEiJ_G0015236
 protein coding gene Chr1:21574457-21652701 (-)
CBA/J MGP_CBAJ_G0015629
 protein coding gene Chr1:23187583-23267948 (-)
DBA/2J MGP_DBA2J_G0015728
 protein coding gene Chr1:20729016-20809169 (-)
FVB/NJ MGP_FVBNJ_G0015732
 protein coding gene Chr1:20498942-20569394 (-)
LP/J MGP_LPJ_G0015800
 protein coding gene Chr1:21872717-21951467 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015752
 protein coding gene Chr1:24205256-24283093 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016324
 protein coding gene Chr1:21355443-21432851 (-)
PWK/PhJ MGP_PWKPhJ_G0015019
 protein coding gene Chr1:20492674-20567455 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014800
 protein coding gene Chr1:21472353-21552572 (-)
WSB/EiJ MGP_WSBEiJ_G0015299
 protein coding gene Chr1:21301725-21375791 (-)



Homology
more
  • Human Ortholog
    SMAP1, small ArfGAP 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMAP1, small ArfGAP 1
  • Synonyms
    SMAP-1
  • Links
    NCBI Gene ID: 60682
    neXtProt AC: NX_Q8IYB5
    UniProt: Q8IYB5

  • Chr Location
    6q13; chr6:70667776-70862015 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    6 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit perturbed receptor trafficking and myelodysplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    10
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026155 Ensembl Gene Model | MGI Sequence Detail 77472 C57BL/6J ±  kb
    transcript ENSMUST00000027339 Ensembl | MGI Sequence Detail 2289 Not Applicable  
    polypeptide ENSMUSP00000027339 Ensembl | MGI Sequence Detail 440 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1918153, MGI:1918155, MGI:1920661
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:79308 Sato Y, et al., Involvement of stromal membrane-associated protein (SMAP-1) in erythropoietic microenvironment. J Biochem. 1998 Jul;124(1):209-16
    • Latest
      J:226700 Sumiyoshi M, et al., Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality. FEBS Lett. 2015 Sep 14;589(19 Pt B):2754-62
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory