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Myl9 Gene Detail
Summary
  • Symbol
    Myl9
  • Name
    myosin, light polypeptide 9, regulatory
  • Synonyms
    MLC20, Mylc2c, RLC-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138915
    NCBI Gene: 98932
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:156617373-156623578 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 77.77 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    299 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138915
 protein coding gene Chr2:156617340-156623578 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026767
 protein coding gene Chr2:161696215-161716889 (+)
A/J MGP_AJ_G0026733
 protein coding gene Chr2:155261162-155267893 (+)
AKR/J MGP_AKRJ_G0026704
 protein coding gene Chr2:159772860-159780669 (+)
BALB/cJ MGP_BALBcJ_G0026742
 protein coding gene Chr2:155548876-155555293 (+)
C3H/HeJ MGP_C3HHeJ_G0026485
 protein coding gene Chr2:160111685-160119781 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027191
 protein coding gene Chr2:166415950-166423143 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024561
 protein coding gene Chr2:148721005-148726969 (+)
CAST/EiJ MGP_CASTEiJ_G0025946
 protein coding gene Chr2:160456442-160462152 (+)
CBA/J MGP_CBAJ_G0026462
 protein coding gene Chr2:172493288-172506141 (+)
DBA/2J MGP_DBA2J_G0026599
 protein coding gene Chr2:154430022-154436775 (+)
FVB/NJ MGP_FVBNJ_G0026566
 protein coding gene Chr2:152800069-152806405 (+)
LP/J MGP_LPJ_G0026704
 protein coding gene Chr2:161818215-161825209 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026587
 protein coding gene Chr2:176376729-176383746 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027247
 protein coding gene Chr2:159635088-159641352 (+)
PWK/PhJ MGP_PWKPhJ_G0025680
 protein coding gene Chr2:153936140-153943933 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025483
 protein coding gene Chr2:158585208-158590901 (+)
WSB/EiJ MGP_WSBEiJ_G0026016
 protein coding gene Chr2:160527805-160535169 (+)



Homology
more
  • Human Ortholog
    MYL9, myosin light chain 9
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYL9, myosin light chain 9
  • Synonyms
    LC20, MLC2, MLC-2C, MMIHS4, MRLC1, MYRL2
  • Links
    NCBI Gene ID: 10398
    neXtProt AC: NX_P24844
    UniProt: P24844

  • Chr Location
    20q11.23; chr20:36541497-36551447 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human MYL9 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die 1 to 4 days after birth with decreased body size and dilated bladder and intestine. Mice homozygous for a conditional allele activated in smooth muscle exhibit premature death with extended duodenum and jejunum, dark liver, and altered vascular and intestinal smooth muscle function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1086
  • Tissues
    185
  • cDNA Data
    172
  • Literature Summary
    55
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 98932 NCBI Gene Model | MGI Sequence Detail 6206 C57BL/6J ±  kb
    transcript NM_001418930 RefSeq | MGI Sequence Detail 1127 C57BL/6  
    polypeptide Q9CQ19 UniProt | EBI | MGI Sequence Detail 172 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 174
      cDNA 172
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36061, MGI:107493
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 55
      Gene Ontology 5
      Phenotypes 7
    • Earliest
      J:18786 Kubalak SW, et al., Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. J Biol Chem. 1994 Jun 17;269(24):16961-70
    • Latest
      J:358135 Guijarro C, et al., Single-cell morphometrics reveals T-box gene-dependent patterns of epithelial tension in the Second Heart field. Nat Commun. 2024 Nov 4;15(1):9512
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory