About   Help   FAQ
Mylk2 Gene Detail
Summary
  • Symbol
    Mylk2
  • Name
    myosin, light polypeptide kinase 2, skeletal muscle
  • Synonyms
    9830004H17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139434
    NCBI Gene: 228785
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152753272-152764988 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139434
 protein coding gene Chr2:152753265-152764988 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026680
 protein coding gene Chr2:157500502-157525119 (+)
A/J MGP_AJ_G0026646
 protein coding gene Chr2:151210674-151222088 (+)
AKR/J MGP_AKRJ_G0026616
 protein coding gene Chr2:155630756-155644117 (+)
BALB/cJ MGP_BALBcJ_G0026655
 protein coding gene Chr2:151520150-151531706 (+)
C3H/HeJ MGP_C3HHeJ_G0026398
 protein coding gene Chr2:156001453-156012970 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027104
 protein coding gene Chr2:162073654-162099101 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024475
 protein coding gene Chr2:144800380-144812732 (+)
CAST/EiJ MGP_CASTEiJ_G0025859
 protein coding gene Chr2:156246177-156270706 (+)
CBA/J MGP_CBAJ_G0026376
 protein coding gene Chr2:168046270-168060101 (+)
DBA/2J MGP_DBA2J_G0026512
 protein coding gene Chr2:150420703-150432180 (+)
FVB/NJ MGP_FVBNJ_G0026478
 protein coding gene Chr2:148885131-148899371 (+)
LP/J MGP_LPJ_G0026616
 protein coding gene Chr2:157647178-157670898 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026499
 protein coding gene Chr2:172108679-172123520 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027160
 protein coding gene Chr2:155512053-155537163 (+)
PWK/PhJ MGP_PWKPhJ_G0025593
 protein coding gene Chr2:149933550-149958311 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025396
 protein coding gene Chr2:154345125-154368753 (+)
WSB/EiJ MGP_WSBEiJ_G0025929
 protein coding gene Chr2:156416623-156441290 (+)



Homology
more
  • Human Ortholog
    MYLK2, myosin light chain kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYLK2, myosin light chain kinase 2
  • Synonyms
    KMLC, MLCK, MLCK2, skMLCK
  • Links
    NCBI Gene ID: 85366
    neXtProt AC: NX_Q9H1R3
    UniProt: Q9H1R3

  • Chr Location
    20q11.21; chr20:31819308-31834689 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MYLK2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout mice display impaired skeletal muscle twitch tension response to tetanic stimulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027470 Ensembl Gene Model | MGI Sequence Detail 11717 C57BL/6J ±  kb
transcript ENSMUST00000028970 Ensembl | MGI Sequence Detail 2951 Not Applicable  
polypeptide ENSMUSP00000028970 Ensembl | MGI Sequence Detail 613 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 35
    Gene Ontology 12
    Phenotypes 7
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:173154 Al Madhoun AS, et al., Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C. EMBO J. 2011;30(12):2477-89
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory