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Tprn Gene Detail
Summary
  • Symbol
    Tprn
  • Name
    taperin
  • Synonyms
    C430004E15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139535
    NCBI Gene: 97031
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25152630-25159897 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139535
 protein coding gene Chr2:25152610-25159898 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025433
 protein coding gene Chr2:23130516-23137771 (+)
A/J MGP_AJ_G0025410
 protein coding gene Chr2:22241766-22249029 (+)
AKR/J MGP_AKRJ_G0025380
 protein coding gene Chr2:22985446-22992700 (+)
BALB/cJ MGP_BALBcJ_G0025406
 protein coding gene Chr2:22352403-22359715 (+)
C3H/HeJ MGP_C3HHeJ_G0025167
 protein coding gene Chr2:22912058-22919316 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025850
 protein coding gene Chr2:23865498-23872756 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023261
 protein coding gene Chr2:21158186-21165405 (+)
CAST/EiJ MGP_CASTEiJ_G0024630
 protein coding gene Chr2:22794165-22801421 (+)
CBA/J MGP_CBAJ_G0025145
 protein coding gene Chr2:24698607-24706001 (+)
DBA/2J MGP_DBA2J_G0025278
 protein coding gene Chr2:22083559-22090820 (+)
FVB/NJ MGP_FVBNJ_G0025240
 protein coding gene Chr2:21824490-21831753 (+)
LP/J MGP_LPJ_G0025364
 protein coding gene Chr2:23075352-23082618 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025271
 protein coding gene Chr2:24903099-24910364 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025909
 protein coding gene Chr2:22932218-22939481 (+)
PWK/PhJ MGP_PWKPhJ_G0024378
 protein coding gene Chr2:21895703-21903027 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024178
 protein coding gene Chr2:23088446-23095702 (+)
WSB/EiJ MGP_WSBEiJ_G0024699
 protein coding gene Chr2:23001040-23008292 (+)



Homology
more
  • Human Ortholog
    TPRN, taperin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPRN, taperin
  • Synonyms
    C9orf75, DFNB79
  • Links
    NCBI Gene ID: 286262
    neXtProt AC: NX_Q4KMQ1
    UniProt: Q4KMQ1

  • Chr Location
    9q34.3; chr9:137191617-137204193 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tprn mouse models; 1 with human TPRN associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hearing loss and degeneration of hair cell stereocilia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    20
  • cDNA Data
    43
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048707 Ensembl Gene Model | MGI Sequence Detail 7268 C57BL/6J ±  kb
transcript ENSMUST00000114336 Ensembl | MGI Sequence Detail 2787 Not Applicable  
polypeptide ENSMUSP00000109975 Ensembl | MGI Sequence Detail 749 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    cDNA 43

    Microarray probesets 4
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory