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Ppm1l Gene Detail
Summary
  • Symbol
    Ppm1l
  • Name
    protein phosphatase 1 (formerly 2C)-like
  • Synonyms
    5930404J21Rik, Pp2ce, PP2C-epsilon
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139740
    NCBI Gene: 242083
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:69224251-69468131 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 32.21 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7645 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139740
 protein coding gene Chr3:69224194-69468135 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027295
 protein coding gene Chr3:68567611-68824291 (+)
A/J MGP_AJ_G0027257
 protein coding gene Chr3:66508942-66754788 (+)
AKR/J MGP_AKRJ_G0027225
 protein coding gene Chr3:67952153-68209355 (+)
BALB/cJ MGP_BALBcJ_G0027268
 protein coding gene Chr3:66390489-66645678 (+)
C3H/HeJ MGP_C3HHeJ_G0027012
 protein coding gene Chr3:68169166-68431301 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027714
 protein coding gene Chr3:71138602-71397173 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025067
 protein coding gene Chr3:62771886-63033140 (+)
CAST/EiJ MGP_CASTEiJ_G0026459
 protein coding gene Chr3:68131728-68399071 (+)
CBA/J MGP_CBAJ_G0026987
 protein coding gene Chr3:73322130-73593345 (+)
DBA/2J MGP_DBA2J_G0027123
 protein coding gene Chr3:66014044-66257367 (+)
FVB/NJ MGP_FVBNJ_G0027091
 protein coding gene Chr3:64638452-64883448 (+)
LP/J MGP_LPJ_G0027231
 protein coding gene Chr3:69495645-69762045 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027110
 protein coding gene Chr3:77922267-78185993 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027772
 protein coding gene Chr3:67833846-68089447 (+)
PWK/PhJ MGP_PWKPhJ_G0026193
 protein coding gene Chr3:65748563-66012388 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026009
 protein coding gene Chr3:66924030-67176297 (+)
WSB/EiJ MGP_WSBEiJ_G0026537
 protein coding gene Chr3:67976420-68234326 (+)



Homology
more
  • Human Ortholog
    PPM1L, protein phosphatase, Mg2+/Mn2+ dependent 1L
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPM1L, protein phosphatase, Mg2+/Mn2+ dependent 1L
  • Synonyms
    PP2CE, PP2C-epsilon, PPM1-LIKE
  • Links
    NCBI Gene ID: 151742
    neXtProt AC: NX_Q5SGD2
    UniProt: Q5SGD2

  • Chr Location
    3q25.33-q26.1; chr3:160755602-161078902 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show increased body weight and total fat mass, higher blood pressure and plasma glucose levels, lower free fatty acid levels and improved glucose tolerance. Homozygotes for another null allele show postnatal lethality, motor deficits and altered forebrain morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1031
  • Tissues
    63
  • cDNA Data
    71
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 242083 NCBI Gene Model | MGI Sequence Detail 243881 C57BL/6J ±  kb
    transcript NM_178726 RefSeq | MGI Sequence Detail 3962 C57BL/6  
    polypeptide Q8BHN0 UniProt | EBI | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 71
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2139948
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:306226 Firulli BA, et al., HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure. Cardiovasc Res. 2020 Mar 1;116(3):605-618
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory