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Ints3 Gene Detail
Summary
  • Symbol
    Ints3
  • Name
    integrator complex subunit 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140050
    NCBI Gene: 229543
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90298691-90340800 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.22 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    950 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140050
 protein coding gene Chr3:90298691-90340929 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027463
 protein coding gene Chr3:90700131-90743749 (-)
A/J MGP_AJ_G0027427
 protein coding gene Chr3:87680603-87723447 (-)
AKR/J MGP_AKRJ_G0027392
 protein coding gene Chr3:89837734-89881378 (-)
BALB/cJ MGP_BALBcJ_G0027436
 protein coding gene Chr3:87636997-87679120 (-)
C3H/HeJ MGP_C3HHeJ_G0027178
 protein coding gene Chr3:90000086-90043772 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027882
 protein coding gene Chr3:94103445-94146527 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025235
 protein coding gene Chr3:83174122-83216884 (-)
CAST/EiJ MGP_CASTEiJ_G0026624
 protein coding gene Chr3:90383158-90430494 (-)
CBA/J MGP_CBAJ_G0027153
 protein coding gene Chr3:97331797-97373889 (-)
DBA/2J MGP_DBA2J_G0027290
 protein coding gene Chr3:87047748-87089767 (-)
FVB/NJ MGP_FVBNJ_G0027258
 protein coding gene Chr3:85382067-85424195 (-)
LP/J MGP_LPJ_G0027399
 protein coding gene Chr3:91764784-91808591 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027279
 protein coding gene Chr3:103548377-103594522 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027941
 protein coding gene Chr3:89579374-89625325 (-)
PWK/PhJ MGP_PWKPhJ_G0026358
 protein coding gene Chr3:86939507-86983420 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026178
 protein coding gene Chr3:88759517-88801113 (-)
WSB/EiJ MGP_WSBEiJ_G0026706
 protein coding gene Chr3:89981624-90025523 (-)



Homology
more
  • Human Ortholog
    INTS3, integrator complex subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INTS3, integrator complex subunit 3
  • Synonyms
    C1orf193, C1orf60, INT3, SOSS-A, SOSSA
  • Links
    NCBI Gene ID: 65123
    neXtProt AC: NX_Q68E01
    UniProt: Q68E01

  • Chr Location
    1q21.3; chr1:153728050-153774808 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    173
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 229543 NCBI Gene Model | MGI Sequence Detail 42110 C57BL/6J ±  kb
transcript NM_145540 RefSeq | MGI Sequence Detail 4313 C57BL/6  
polypeptide Q7TPD0 UniProt | EBI | MGI Sequence Detail 1041 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 173
    cDNA 173

    Microarray probesets 4
References
more
  • Summaries
    All 38
    Diseases 1
    Gene Ontology 5
    Phenotypes 13
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory