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Tdrd7 Gene Detail
Summary
  • Symbol
    Tdrd7
  • Name
    tudor domain containing 7
  • Synonyms
    5730495N10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140279
    NCBI Gene: 100121
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:45965334-46034761 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 24.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1637 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140279
 protein coding gene Chr4:45965334-46034766 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028250
 protein coding gene Chr4:44235790-44308259 (+)
A/J MGP_AJ_G0028209
 protein coding gene Chr4:42639431-42707952 (+)
AKR/J MGP_AKRJ_G0028159
 protein coding gene Chr4:43661107-43737865 (+)
BALB/cJ MGP_BALBcJ_G0028229
 protein coding gene Chr4:42722821-42803020 (+)
C3H/HeJ MGP_C3HHeJ_G0027950
 protein coding gene Chr4:44272504-44344665 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028670
 protein coding gene Chr4:45875400-45952304 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025979
 protein coding gene Chr4:40029779-40097782 (+)
CAST/EiJ MGP_CASTEiJ_G0027389
 protein coding gene Chr4:43825471-43898019 (+)
CBA/J MGP_CBAJ_G0027916
 protein coding gene Chr4:47323895-47401421 (+)
DBA/2J MGP_DBA2J_G0028066
 protein coding gene Chr4:42532098-42602023 (+)
FVB/NJ MGP_FVBNJ_G0028033
 protein coding gene Chr4:41772736-41843277 (+)
LP/J MGP_LPJ_G0028165
 protein coding gene Chr4:44288366-44363919 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028057
 protein coding gene Chr4:50437418-50516863 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028705
 protein coding gene Chr4:43883884-43957048 (+)
PWK/PhJ MGP_PWKPhJ_G0027114
 protein coding gene Chr4:42619685-42690080 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026942
 protein coding gene Chr4:43380382-43449959 (+)
WSB/EiJ MGP_WSBEiJ_G0027467
 protein coding gene Chr4:43783780-43858022 (+)



Homology
more
  • Human Ortholog
    TDRD7, tudor domain containing 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TDRD7, tudor domain containing 7
  • Synonyms
    CATC4, PCTAIRE2BP, TRAP
  • Links
    NCBI Gene ID: 23424
    neXtProt AC: NX_Q8NHU6
    UniProt: Q8NHU6

  • Chr Location
    9q22.33; chr9:97412096-97496125 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TDRD7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    6 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes arrest of spermatogenesis, male sterility, glaucoma, and cataracts. Aging mice homozygous for an ENU-induced (null) allele show additional ocular phenotypes including an enlarged anterior chamber, lens extrusion, a flat iris, uveitis, and optic neuropathy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    34
  • cDNA Data
    88
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035517 Ensembl Gene Model | MGI Sequence Detail 69428 C57BL/6J ±  kb
    transcript ENSMUST00000107777 Ensembl | MGI Sequence Detail 3655 Not Applicable  
    polypeptide ENSMUSP00000103406 Ensembl | MGI Sequence Detail 1119 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      cDNA 88
      Primer pair 1
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:68708 Hrabe de Angelis MH, et al., Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet. 2000 Aug;25(4):444-7
    • Latest
      J:308692 Anand D, et al., Genome-Wide Analysis of Differentially Expressed miRNAs and Their Associated Regulatory Networks in Lenses Deficient for the Congenital Cataract-Linked Tudor Domain Containing Protein TDRD7. Front Cell Dev Biol. 2021;9:615761
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory