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Acacb Gene Detail
Summary
  • Symbol
    Acacb
  • Name
    acetyl-Coenzyme A carboxylase beta
  • Synonyms
    Acc2, Accb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140940
    NCBI Gene: 100705
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:114284748-114388822 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 55.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3548 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140940
 protein coding gene Chr5:114284596-114388822 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029933
 protein coding gene Chr5:116859920-116971015 (+)
A/J MGP_AJ_G0029898
 protein coding gene Chr5:112276820-112383377 (+)
AKR/J MGP_AKRJ_G0029836
 protein coding gene Chr5:115842948-115951782 (+)
BALB/cJ MGP_BALBcJ_G0029909
 protein coding gene Chr5:113645080-113751625 (+)
C3H/HeJ MGP_C3HHeJ_G0029629
 protein coding gene Chr5:116335447-116454319 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030363
 protein coding gene Chr5:121379446-121500298 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027591
 protein coding gene Chr5:107101676-107208085 (+)
CAST/EiJ MGP_CASTEiJ_G0029037
 protein coding gene Chr5:115268835-115385757 (+)
CBA/J MGP_CBAJ_G0029596
 protein coding gene Chr5:125985784-126118305 (+)
DBA/2J MGP_DBA2J_G0029746
 protein coding gene Chr5:112335970-112444723 (+)
FVB/NJ MGP_FVBNJ_G0029703
 protein coding gene Chr5:111134056-111244999 (+)
LP/J MGP_LPJ_G0029835
 protein coding gene Chr5:117428909-117539602 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029734
 protein coding gene Chr5:130454127-130571666 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030404
 protein coding gene Chr5:115301069-115416389 (+)
PWK/PhJ MGP_PWKPhJ_G0028751
 protein coding gene Chr5:110966054-111074087 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028589
 protein coding gene Chr5:112844128-112954782 (+)
WSB/EiJ MGP_WSBEiJ_G0029113
 protein coding gene Chr5:115866127-115983537 (+)



Homology
more
  • Human Ortholog
    ACACB, acetyl-CoA carboxylase beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACACB, acetyl-CoA carboxylase beta
  • Synonyms
    ACACbeta, ACC2, ACCB, ACC-beta, ACCbeta, HACC275
  • Links
    NCBI Gene ID: 32
    neXtProt AC: NX_O00763
    UniProt: O00763

  • Chr Location
    12q24.11; chr12:109111189-109268226 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable, fertile and overtly normal but exhibit high levels of fatty acid oxidation, as well as reduced fat accumulation in their adipose tissue and liver, and decreased storage of glycogen in their liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    96
  • cDNA Data
    10
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 100705 NCBI Gene Model | MGI Sequence Detail 104075 C57BL/6J ±  kb
    transcript NM_001403527 RefSeq | MGI Sequence Detail 8699 C57BL/6  
    polypeptide E9Q4Z2 UniProt | EBI | MGI Sequence Detail 2448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 10
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141247
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 12
      Gene Ontology 14
      Phenotypes 46
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:346743 Deja S, et al., Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability. Cell Metab. 2024 Mar 1;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory