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Styk1 Gene Detail
Summary
  • Symbol
    Styk1
  • Name
    serine/threonine/tyrosine kinase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141396
    NCBI Gene: 243659
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:131276096-131330532 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1967 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141396
 protein coding gene Chr6:131276096-131330560 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031367
 protein coding gene Chr6:135229385-135285892 (-)
A/J MGP_AJ_G0031344
 protein coding gene Chr6:129976785-130031144 (-)
AKR/J MGP_AKRJ_G0031272
 protein coding gene Chr6:133764059-133818505 (-)
BALB/cJ MGP_BALBcJ_G0031351
 protein coding gene Chr6:129649126-129704154 (-)
C3H/HeJ MGP_C3HHeJ_G0031074
 protein coding gene Chr6:133850900-133906893 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031809
 protein coding gene Chr6:138847789-138903336 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028946
 protein coding gene Chr6:128269422-128324117 (-)
CAST/EiJ MGP_CASTEiJ_G0030445
 protein coding gene Chr6:133765012-133822260 (-)
CBA/J MGP_CBAJ_G0031032
 protein coding gene Chr6:144174916-144235254 (-)
DBA/2J MGP_DBA2J_G0031192
 protein coding gene Chr6:128886585-128940169 (-)
FVB/NJ MGP_FVBNJ_G0031141
 protein coding gene Chr6:127787561-127842488 (-)
LP/J MGP_LPJ_G0031272
 protein coding gene Chr6:135541609-135596632 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0031842
 protein coding gene Chr6:133634638-133694492 (-)
PWK/PhJ MGP_PWKPhJ_G0030165
 protein coding gene Chr6:127280020-127331441 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029993
 protein coding gene Chr6:131888085-131946492 (-)
WSB/EiJ MGP_WSBEiJ_G0030532
 protein coding gene Chr6:134207689-134272291 (-)



Homology
more
  • Human Ortholog
    STYK1, serine/threonine/tyrosine kinase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STYK1, serine/threonine/tyrosine kinase 1
  • Synonyms
    NOK, SuRTK106
  • Links
    NCBI Gene ID: 55359
    neXtProt AC: NX_Q6J9G0
    UniProt: Q6J9G0

  • Chr Location
    12p13.2; chr12:10618923-10674318 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotype references
Homozygous inactivation of this gene results in viable mice with normal NK cell development and effector functions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    6
  • cDNA Data
    9
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 243659 NCBI Gene Model | MGI Sequence Detail 54437 C57BL/6J ±  kb
transcript NM_172891 RefSeq | MGI Sequence Detail 3576 C57BL/6  
polypeptide Q6J9G1 UniProt | EBI | MGI Sequence Detail 429 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:162220 Magdaleno S, et al., BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
  • Latest
    J:328132 Yang Y, et al., Induction of chronic lymphocytic leukemia-like disease in STYK1/NOK transgenic mice. Biochem Biophys Res Commun. 2022 Oct 20;626:51-57
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory