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Nars2 Gene Detail
Summary
  • Symbol
    Nars2
  • Name
    asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142075
    NCBI Gene: 244141
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:96600712-96713965 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 53.13 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2705 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142075
 protein coding gene Chr7:96600698-96725606 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032518
 protein coding gene Chr7:99642384-99757423 (+)
A/J MGP_AJ_G0032492
 protein coding gene Chr7:97170396-97282839 (+)
AKR/J MGP_AKRJ_G0032428
 protein coding gene Chr7:99466712-99587562 (+)
BALB/cJ MGP_BALBcJ_G0032503
 protein coding gene Chr7:96860216-96975374 (+)
C3H/HeJ MGP_C3HHeJ_G0032218
 protein coding gene Chr7:99844114-99959630 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033001
 protein coding gene Chr7:103502247-103628973 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029996
 protein coding gene Chr7:99654558-99763385 (+)
CAST/EiJ MGP_CASTEiJ_G0031545
 protein coding gene Chr7:91364209-91478791 (+)
CBA/J MGP_CBAJ_G0032185
 protein coding gene Chr7:107004129-107143715 (+)
DBA/2J MGP_DBA2J_G0032337
 protein coding gene Chr7:95539865-95668327 (+)
FVB/NJ MGP_FVBNJ_G0032293
 protein coding gene Chr7:95322621-95435383 (+)
LP/J MGP_LPJ_G0032426
 protein coding gene Chr7:100964883-101076600 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032326
 protein coding gene Chr7:108571664-108689897 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033023
 protein coding gene Chr7:98787785-98909541 (+)
PWK/PhJ MGP_PWKPhJ_G0031263
 protein coding gene Chr7:88597930-88713820 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031106
 protein coding gene Chr7:86033197-86150082 (+)
WSB/EiJ MGP_WSBEiJ_G0031662
 protein coding gene Chr7:99425590-99536374 (+)



Homology
more
  • Human Ortholog
    NARS2, asparaginyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NARS2, asparaginyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    asnRS, DFNB94, SLM5
  • Links
    NCBI Gene ID: 79731
    neXtProt AC: NX_Q96I59
    UniProt: Q96I59

  • Chr Location
    11q14.1; chr11:78435620-78575194 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human NARS2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    105
  • cDNA Data
    27
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018995 Ensembl Gene Model | MGI Sequence Detail 113254 C57BL/6J ±  kb
    transcript ENSMUST00000044466 Ensembl | MGI Sequence Detail 3778 Not Applicable  
    polypeptide ENSMUSP00000044937 Ensembl | MGI Sequence Detail 477 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000030931 asparagine--tRNA ligase, mitochondrial
      (term hierarchy)
    • EC
      6.1.1.22
    • InterPro Domains
      IPR006195 Aminoacyl-tRNA synthetase, class II
      IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
      IPR004522 Asparagine-tRNA ligase
      IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb
      IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
      IPR012340 Nucleic acid-binding, OB-fold
      IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
    • GlyGen
      Q8BGV0 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 27
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 30
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory