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Crtc1 Gene Detail
Summary
  • Symbol
    Crtc1
  • Name
    CREB regulated transcription coactivator 1
  • Synonyms
    Mect1, mKIAA0616, TORC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142523
    NCBI Gene: 382056
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:70835005-70892229 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1015 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142523
 protein coding gene Chr8:70835002-70892720 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033704
 protein coding gene Chr8:70648132-70707175 (-)
A/J MGP_AJ_G0033687
 protein coding gene Chr8:67777077-67835536 (-)
AKR/J MGP_AKRJ_G0033612
 protein coding gene Chr8:69704713-69761744 (-)
BALB/cJ MGP_BALBcJ_G0033683
 protein coding gene Chr8:67997866-68055445 (-)
C3H/HeJ MGP_C3HHeJ_G0033393
 protein coding gene Chr8:70350266-70410440 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034200
 protein coding gene Chr8:73318481-73380489 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031144
 protein coding gene Chr8:62593832-62652628 (-)
CAST/EiJ MGP_CASTEiJ_G0032718
 protein coding gene Chr8:69835882-69895547 (-)
CBA/J MGP_CBAJ_G0033371
 protein coding gene Chr8:75948444-76014832 (-)
DBA/2J MGP_DBA2J_G0033525
 protein coding gene Chr8:67497972-67555616 (-)
FVB/NJ MGP_FVBNJ_G0033466
 protein coding gene Chr8:66608605-66669691 (-)
LP/J MGP_LPJ_G0033612
 protein coding gene Chr8:70675571-70734767 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033509
 protein coding gene Chr8:78617100-78682961 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034218
 protein coding gene Chr8:69891588-69950150 (-)
PWK/PhJ MGP_PWKPhJ_G0032426
 protein coding gene Chr8:66793977-66852430 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032262
 protein coding gene Chr8:68859932-68918472 (-)
WSB/EiJ MGP_WSBEiJ_G0032833
 protein coding gene Chr8:70249485-70308960 (-)



Homology
more
  • Human Ortholog
    CRTC1, CREB regulated transcription coactivator 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRTC1, CREB regulated transcription coactivator 1
  • Synonyms
    Mam-2, MAML2, MECT1, TORC-1, TORC1, WAMTP1
  • Links
    NCBI Gene ID: 23373
    neXtProt AC: NX_Q6UUV9
    UniProt: Q6UUV9

  • Chr Location
    19p13.11; chr19:18683678-18782333 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Crtc1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an inactivating mutation in this gene are hyperphagic, obese and infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    87
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003575 Ensembl Gene Model | MGI Sequence Detail 57225 C57BL/6J ±  kb
    transcript ENSMUST00000076615 Ensembl | MGI Sequence Detail 5683 Not Applicable  
    polypeptide ENSMUSP00000075916 Ensembl | MGI Sequence Detail 630 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005901 CREB-regulated transcription coactivator 1
      (term hierarchy)
    • InterPro Domains
      IPR024786 CREB-regulated transcription coactivator
      IPR024785 Transducer of regulated CREB activity, C-terminal
      IPR024784 Transducer of regulated CREB activity, middle domain
      IPR024783 Transducer of regulated CREB activity, N-terminal
    • GlyGen
      Q68ED7 4 sites, 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 87

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142895
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory