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Gpat4 Gene Detail
Summary
  • Symbol
    Gpat4
  • Name
    glycerol-3-phosphate acyltransferase 4
  • Synonyms
    Agpat6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142716
    NCBI Gene: 102247
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:23661281-23698362 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    896 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142716
 protein coding gene Chr8:23661281-23698469 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033463
 protein coding gene Chr8:21071574-21110009 (-)
A/J MGP_AJ_G0033443
 protein coding gene Chr8:20372066-20408673 (-)
AKR/J MGP_AKRJ_G0033368
 protein coding gene Chr8:21040431-21080441 (-)
BALB/cJ MGP_BALBcJ_G0033439
 protein coding gene Chr8:20494932-20530480 (-)
C3H/HeJ MGP_C3HHeJ_G0033153
 protein coding gene Chr8:21241938-21277597 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033955
 protein coding gene Chr8:21935605-21976726 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030906
 protein coding gene Chr8:17714202-17733184 (-)
CAST/EiJ MGP_CASTEiJ_G0032479
 protein coding gene Chr8:20674003-20708827 (-)
CBA/J MGP_CBAJ_G0033128
 protein coding gene Chr8:22816725-22855088 (-)
DBA/2J MGP_DBA2J_G0033283
 protein coding gene Chr8:20341124-20376270 (-)
FVB/NJ MGP_FVBNJ_G0033227
 protein coding gene Chr8:20139976-20175672 (-)
LP/J MGP_LPJ_G0033372
 protein coding gene Chr8:21065537-21102765 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033270
 protein coding gene Chr8:22379585-22417142 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033974
 protein coding gene Chr8:20946855-20988419 (-)
PWK/PhJ MGP_PWKPhJ_G0032191
 protein coding gene Chr8:19934852-19970444 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032024
 protein coding gene Chr8:20321886-20355788 (-)
WSB/EiJ MGP_WSBEiJ_G0032595
 protein coding gene Chr8:21154862-21192652 (-)



Homology
more
  • Human Ortholog
    GPAT4, glycerol-3-phosphate acyltransferase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPAT4, glycerol-3-phosphate acyltransferase 4
  • Synonyms
    1-AGPAT 6, AGPAT6, LPAATZ, LPAAT-zeta, TSARG7
  • Links
    NCBI Gene ID: 137964
    neXtProt AC: NX_Q86UL3
    UniProt: Q86UL3

  • Chr Location
    8p11.21; chr8:41577187-41625001 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nursing mothers homozygous for a gene trap allele display underdeveloped mammary glands that are depleted in intracellular fat droplets and lack the ability to produce diacylglycerol- and triacylglycerol-rich milk; pups nursed by mutant mothers die neonatally unless transferred to foster mothers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    27
  • cDNA Data
    222
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031545 Ensembl Gene Model | MGI Sequence Detail 37082 C57BL/6J ±  kb
    transcript ENSMUST00000167004 Ensembl | MGI Sequence Detail 5518 Not Applicable  
    polypeptide ENSMUSP00000127325 Ensembl | MGI Sequence Detail 456 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 224
      cDNA 222
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142801
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:311438 Quiroga IY, et al., Triacylglycerol synthesis directed by glycerol-3-phosphate acyltransferases -3 and -4 is required for lipid droplet formation and the modulation of the inflammatory response during macrophage to foam cell transition. Atherosclerosis. 2021 Jan;316:1-7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory