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Cog4 Gene Detail
Summary
  • Symbol
    Cog4
  • Name
    component of oligomeric golgi complex 4
  • Synonyms
    D8Ertd515e
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142808
    NCBI Gene: 102339
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:111573232-111608859 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.76 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1178 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142808
 protein coding gene Chr8:111573232-111608866 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034129
 protein coding gene Chr8:113537300-113573939 (+)
A/J MGP_AJ_G0034108
 protein coding gene Chr8:108940418-108985238 (+)
AKR/J MGP_AKRJ_G0034035
 protein coding gene Chr8:112131574-112168475 (+)
BALB/cJ MGP_BALBcJ_G0034102
 protein coding gene Chr8:109129822-109165299 (+)
C3H/HeJ MGP_C3HHeJ_G0033813
 protein coding gene Chr8:112847986-112883666 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034622
 protein coding gene Chr8:117531633-117569887 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031564
 protein coding gene Chr8:101932785-101968439 (+)
CAST/EiJ MGP_CASTEiJ_G0033140
 protein coding gene Chr8:112462638-112501855 (+)
CBA/J MGP_CBAJ_G0033787
 protein coding gene Chr8:121519428-121560923 (+)
DBA/2J MGP_DBA2J_G0033942
 protein coding gene Chr8:108241869-108277146 (+)
FVB/NJ MGP_FVBNJ_G0033886
 protein coding gene Chr8:107197571-107234023 (+)
LP/J MGP_LPJ_G0034032
 protein coding gene Chr8:113726878-113765532 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033932
 protein coding gene Chr8:124429729-124470159 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034641
 protein coding gene Chr8:112101484-112137432 (+)
PWK/PhJ MGP_PWKPhJ_G0032843
 protein coding gene Chr8:107820784-107858618 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032682
 protein coding gene Chr8:110784914-110824365 (+)
WSB/EiJ MGP_WSBEiJ_G0033256
 protein coding gene Chr8:112789020-112825513 (+)



Homology
more
  • Human Ortholog
    COG4, component of oligomeric golgi complex 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COG4, component of oligomeric golgi complex 4
  • Synonyms
    CDG2J, COD1, SWILS
  • Links
    NCBI Gene ID: 25839
    neXtProt AC: NX_Q9H9E3
    UniProt: Q9H9E3

  • Chr Location
    16q22.1; chr16:70480567-70523560 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human COG4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    129
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031753 Ensembl Gene Model | MGI Sequence Detail 35628 C57BL/6J ±  kb
    transcript ENSMUST00000034203 Ensembl | MGI Sequence Detail 2737 Not Applicable  
    polypeptide ENSMUSP00000034203 Ensembl | MGI Sequence Detail 785 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000005687 conserved oligomeric Golgi complex subunit 4
      (term hierarchy)
    • InterPro Domains
      IPR013167 COG4 transport protein, middle alpha-helical bundle
      IPR048682 Conserved oligomeric Golgi complex subunit 4
      IPR048684 Conserved oligomeric Golgi complex subunit 4, C-terminal
      IPR048680 Conserved oligomeric Golgi complex subunit 4, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 130
      cDNA 129
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1261770
    References
    more
    • Summaries
      All 32
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory