About   Help   FAQ
Tafa2 Gene Detail
Summary
  • Symbol
    Tafa2
  • Name
    TAFA chemokine like family member 2
  • Synonyms
    Fam19a2, Sam2, Tafa-2, Tafa2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143691
    NCBI Gene: 268354
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:123099901-123577109 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 72.31 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    15119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143691
 protein coding gene Chr10:123099813-123577109 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017793
 protein coding gene Chr10:126620391-127123281 (+)
A/J MGP_AJ_G0017768
 protein coding gene Chr10:121558355-122043731 (+)
AKR/J MGP_AKRJ_G0017731
 protein coding gene Chr10:125196306-125696367 (+)
BALB/cJ MGP_BALBcJ_G0017732
 protein coding gene Chr10:121985979-122477138 (+)
C3H/HeJ MGP_C3HHeJ_G0017556
 protein coding gene Chr10:125400581-125901211 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018187
 protein coding gene Chr10:130891485-131405780 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015867
 protein coding gene Chr10:115818938-116282277 (+)
CAST/EiJ MGP_CASTEiJ_G0017116
 protein coding gene Chr10:125814994-126332867 (+)
CBA/J MGP_CBAJ_G0017525
 protein coding gene Chr10:136237981-136782099 (+)
DBA/2J MGP_DBA2J_G0017631
 protein coding gene Chr10:120692674-121177460 (+)
FVB/NJ MGP_FVBNJ_G0017626
 protein coding gene Chr10:119669206-120139446 (+)
LP/J MGP_LPJ_G0017705
 protein coding gene Chr10:127152767-127663059 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017654
 protein coding gene Chr10:138724444-139284776 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018227
 protein coding gene Chr10:125242605-125744046 (+)
PWK/PhJ MGP_PWKPhJ_G0016901
 protein coding gene Chr10:120819783-121312264 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016693
 protein coding gene Chr10:124161116-124707291 (+)
WSB/EiJ MGP_WSBEiJ_G0017177
 protein coding gene Chr10:125422206-125918484 (+)



Homology
more
  • Human Ortholog
    TAFA2, TAFA chemokine like family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAFA2, TAFA chemokine like family member 2
  • Synonyms
    FAM19A2, TAFA-2
  • Links
    NCBI Gene ID: 338811
    neXtProt AC: NX_Q8N3H0
    UniProt: Q8N3H0

  • Chr Location
    12q14.1; chr12:61708273-62279150 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired spatial learning and memory, impaired memory in novel object recognition test, increased anxiety, decreased depression-like behavior, neuronal loss and increased brain apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    11
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044071 Ensembl Gene Model | MGI Sequence Detail 477209 C57BL/6J ±  kb
    transcript ENSMUST00000050756 Ensembl | MGI Sequence Detail 4364 Not Applicable  
    polypeptide ENSMUSP00000050199 Ensembl | MGI Sequence Detail 135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:6276242
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 4
      Gene Ontology 2
      Phenotypes 8
    • Earliest
      J:90490 Tom Tang Y, et al., TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. Genomics. 2004 Apr;83(4):727-34
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory