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Enpp3 Gene Detail
Summary
  • Symbol
    Enpp3
  • Name
    ectonucleotide pyrophosphatase/phosphodiesterase 3
  • Synonyms
    CD203c, MGC:6548
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143702
    NCBI Gene: 209558
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:24649712-24712093 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 12.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2206 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143702
 protein coding gene Chr10:24648304-24718721 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017094
 protein coding gene Chr10:22766368-22836127 (-)
A/J MGP_AJ_G0017071
 protein coding gene Chr10:22098761-22162951 (-)
AKR/J MGP_AKRJ_G0017031
 protein coding gene Chr10:22464673-22530436 (-)
BALB/cJ MGP_BALBcJ_G0017034
 protein coding gene Chr10:22190168-22252924 (-)
C3H/HeJ MGP_C3HHeJ_G0016854
 protein coding gene Chr10:22674696-22740343 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017492
 protein coding gene Chr10:23469705-23539909 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015190
 protein coding gene Chr10:20785993-20850328 (-)
CAST/EiJ MGP_CASTEiJ_G0016433
 protein coding gene Chr10:22610318-22677280 (-)
CBA/J MGP_CBAJ_G0016828
 protein coding gene Chr10:24533132-24602309 (-)
DBA/2J MGP_DBA2J_G0016933
 protein coding gene Chr10:21825898-21889951 (-)
FVB/NJ MGP_FVBNJ_G0016928
 protein coding gene Chr10:21529891-21593020 (-)
LP/J MGP_LPJ_G0017010
 protein coding gene Chr10:22756324-22823603 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016958
 protein coding gene Chr10:24636898-24717257 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017528
 protein coding gene Chr10:22320422-22385065 (-)
PWK/PhJ MGP_PWKPhJ_G0016215
 protein coding gene Chr10:21604201-21679307 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015999
 protein coding gene Chr10:22126113-22201193 (-)
WSB/EiJ MGP_WSBEiJ_G0016496
 protein coding gene Chr10:22438364-22512718 (-)



Homology
more
  • Human Ortholog
    ENPP3, ectonucleotide pyrophosphatase/phosphodiesterase 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENPP3, ectonucleotide pyrophosphatase/phosphodiesterase 3
  • Synonyms
    B10, CD203c, NPP3, PD-IBETA, PDNP3
  • Links
    NCBI Gene ID: 5169
    neXtProt AC: NX_O14638
    UniProt: O14638

  • Chr Location
    6q23.2; chr6:131628442-131747418 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit increased numbers of basophils and mast cells with increased susceptibility to chronic allergic responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    95
  • cDNA Data
    70
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 209558 NCBI Gene Model | MGI Sequence Detail 62382 C57BL/6J ±  kb
    transcript NM_134005 RefSeq | MGI Sequence Detail 2815 C57BL/6  
    polypeptide Q6DYE8 UniProt | EBI | MGI Sequence Detail 874 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 70
      Primer pair 2

      Microarray probesets 6
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:349427 Mardjuki R, et al., Identification of the extracellular membrane protein ENPP3 as a major cGAMP hydrolase and innate immune checkpoint. Cell Rep. 2024 May 28;43(5):114209
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory