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Tbc1d10a Gene Detail
Summary
  • Symbol
    Tbc1d10a
  • Name
    TBC1 domain family, member 10a
  • Synonyms
    EPI64, Tbc1d10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144164
    NCBI Gene: 103724
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:4136789-4165505 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    568 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144164
 protein coding gene Chr11:4136789-4167407 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017978
 protein coding gene Chr11:1119680-1148087 (+)
A/J MGP_AJ_G0017951
 protein coding gene Chr11:1129841-1160099 (+)
AKR/J MGP_AKRJ_G0017915
 protein coding gene Chr11:1185418-1213932 (+)
BALB/cJ MGP_BALBcJ_G0017919
 protein coding gene Chr11:1098838-1129466 (+)
C3H/HeJ MGP_C3HHeJ_G0017732
 protein coding gene Chr11:1080892-1111828 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018372
 protein coding gene Chr11:1199563-1228069 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016030
 protein coding gene Chr11:1010237-1039042 (+)
CAST/EiJ MGP_CASTEiJ_G0017294
 protein coding gene Chr11:1045002-1073540 (+)
CBA/J MGP_CBAJ_G0017707
 protein coding gene Chr11:1445343-1477172 (+)
DBA/2J MGP_DBA2J_G0017818
 protein coding gene Chr11:1035289-1064030 (+)
FVB/NJ MGP_FVBNJ_G0017809
 protein coding gene Chr11:1067573-1096280 (+)
LP/J MGP_LPJ_G0017888
 protein coding gene Chr11:1224108-1253779 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017835
 protein coding gene Chr11:1113280-1142586 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018411
 protein coding gene Chr11:1193076-1221812 (+)
PWK/PhJ MGP_PWKPhJ_G0017075
 protein coding gene Chr11:1037507-1066106 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016871
 protein coding gene Chr11:1149648-1184366 (+)
WSB/EiJ MGP_WSBEiJ_G0017348
 protein coding gene Chr11:1057456-1086194 (+)



Homology
more
  • Human Ortholog
    TBC1D10A, TBC1 domain family member 10A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBC1D10A, TBC1 domain family member 10A
  • Synonyms
    dJ130H16.1, dJ130H16.2, EPI64, TBC1D10
  • Links
    NCBI Gene ID: 83874
    neXtProt AC: NX_Q9BXI6
    UniProt: Q9BXI6

  • Chr Location
    22q12.2; chr22:30291990-30326947 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased circulating LDL cholesterol levels, decreased circulating alanine transaminase and alkaline phosphatase levels, abnormal liver physiology, and increased chromosomal stability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    2
  • cDNA Data
    48
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034412 Ensembl Gene Model | MGI Sequence Detail 28717 C57BL/6J ±  kb
    transcript ENSMUST00000041042 Ensembl | MGI Sequence Detail 1957 Not Applicable  
    polypeptide ENSMUSP00000036861 Ensembl | MGI Sequence Detail 534 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 48

      Microarray probesets 3
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory