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Wdpcp Gene Detail
Summary
  • Symbol
    Wdpcp
  • Name
    WD repeat containing planar cell polarity effector
  • Synonyms
    AV249152, homoloc-13
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144467
    NCBI Gene: 216560
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:21521969-21848686 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 13.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7439 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144467
 protein coding gene Chr11:21521969-21848989 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018074
 protein coding gene Chr11:19205584-19539570 (+)
A/J MGP_AJ_G0018047
 protein coding gene Chr11:18498163-18815954 (+)
AKR/J MGP_AKRJ_G0018011
 protein coding gene Chr11:19165289-19503736 (+)
BALB/cJ MGP_BALBcJ_G0018015
 protein coding gene Chr11:18633196-18955445 (+)
C3H/HeJ MGP_C3HHeJ_G0017829
 protein coding gene Chr11:19031432-19375120 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018467
 protein coding gene Chr11:20048225-20402877 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016125
 protein coding gene Chr11:17444434-17778564 (+)
CAST/EiJ MGP_CASTEiJ_G0017390
 protein coding gene Chr11:19040422-19400572 (+)
CBA/J MGP_CBAJ_G0017803
 protein coding gene Chr11:20907718-21284612 (+)
DBA/2J MGP_DBA2J_G0017913
 protein coding gene Chr11:18445823-18770521 (+)
FVB/NJ MGP_FVBNJ_G0017905
 protein coding gene Chr11:18209303-18536076 (+)
LP/J MGP_LPJ_G0017984
 protein coding gene Chr11:19362094-19702874 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017931
 protein coding gene Chr11:21341263-21732451 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018508
 protein coding gene Chr11:19260817-19598827 (+)
PWK/PhJ MGP_PWKPhJ_G0017171
 protein coding gene Chr11:18472943-18796084 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016968
 protein coding gene Chr11:18992335-19347767 (+)
WSB/EiJ MGP_WSBEiJ_G0017444
 protein coding gene Chr11:18890945-19228553 (+)



Homology
more
  • Human Ortholog
    WDPCP, WD repeat containing planar cell polarity effector
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDPCP, WD repeat containing planar cell polarity effector
  • Synonyms
    BBS15, C2orf86, CHDTHP, CPLANE5, FRITZ, FRTZ
  • Links
    NCBI Gene ID: 51057
    neXtProt AC: NX_O95876
    UniProt: O95876

  • Chr Location
    2p15; chr2:63119559-63840826 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human WDPCP associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display ciliogenesis defects, anophthalmia, cysts in multiple tissues, central polydactyly, duplex kidney, and septation defects in the outflow tract and cloaca.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    833
  • Tissues
    35
  • cDNA Data
    22
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 216560 NCBI Gene Model | MGI Sequence Detail 326718 C57BL/6J ±  kb
    transcript NM_145425 RefSeq | MGI Sequence Detail 2443 ZRU/MplStud  
    polypeptide Q8C456 UniProt | EBI | MGI Sequence Detail 722 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000030333 WD repeat-containing and planar cell polarity effector protein fritz homolog
      (term hierarchy)
    • PDB
      7Q3E
    • InterPro Domains
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
      IPR024511 WD repeat-containing and planar cell polarity effector protein Fritz
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 22
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:352395 Langousis G, et al., Structure of the ciliogenesis-associated CPLANE complex. Sci Adv. 2022 Apr 15;8(15):eabn0832
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/19/2024
    MGI 6.24     		The Jackson Laboratory