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Plekhh1 Gene Detail
Summary
  • Symbol
    Plekhh1
  • Name
    pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
  • Synonyms
    D630024D12Rik, mKIAA1200
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144989
    NCBI Gene: 211945
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:79075937-79128429 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 35.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1447 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144989
 protein coding gene Chr12:79075937-79128429 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019877
 protein coding gene Chr12:79314294-79367094 (+)
A/J MGP_AJ_G0019835
 protein coding gene Chr12:76457079-76508567 (+)
AKR/J MGP_AKRJ_G0019810
 protein coding gene Chr12:78535974-78585385 (+)
BALB/cJ MGP_BALBcJ_G0019814
 protein coding gene Chr12:76716990-76767210 (+)
C3H/HeJ MGP_C3HHeJ_G0019620
 protein coding gene Chr12:79008265-79057857 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020266
 protein coding gene Chr12:81657174-81710410 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017885
 protein coding gene Chr12:73482152-73534458 (+)
CAST/EiJ MGP_CASTEiJ_G0019170
 protein coding gene Chr12:73839693-73893832 (+)
CBA/J MGP_CBAJ_G0019591
 protein coding gene Chr12:84842102-84898552 (+)
DBA/2J MGP_DBA2J_G0019706
 protein coding gene Chr12:76087372-76137281 (+)
FVB/NJ MGP_FVBNJ_G0019692
 protein coding gene Chr12:74899996-74950651 (+)
LP/J MGP_LPJ_G0019778
 protein coding gene Chr12:79248163-79297801 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019731
 protein coding gene Chr12:87892222-87943027 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020301
 protein coding gene Chr12:78048979-78098922 (+)
PWK/PhJ MGP_PWKPhJ_G0018936
 protein coding gene Chr12:70442438-70491712 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018730
 protein coding gene Chr12:72560148-72609564 (+)
WSB/EiJ MGP_WSBEiJ_G0019223
 protein coding gene Chr12:78665250-78715813 (+)



Homology
more
  • Human Ortholog
    PLEKHH1, pleckstrin homology, MyTH4 and FERM domain containing H1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLEKHH1, pleckstrin homology, MyTH4 and FERM domain containing H1
  • Links
    NCBI Gene ID: 57475
    neXtProt AC: NX_Q9ULM0
    UniProt: Q9ULM0

  • Chr Location
    14q24.1; chr14:67533290-67589612 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    742
  • Tissues
    36
  • cDNA Data
    50
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 211945 NCBI Gene Model | MGI Sequence Detail 52493 C57BL/6J ±  kb
transcript NM_181073 RefSeq | MGI Sequence Detail 6451 C57BL/6  
polypeptide Q80TI1 UniProt | EBI | MGI Sequence Detail 1356 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    cDNA 50

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145084
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 13
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:355142 Gomez-Del Arco P, et al., The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory