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Cdk20 Gene Detail
Summary
  • Symbol
    Cdk20
  • Name
    cyclin dependent kinase 20
  • Synonyms
    4932702G04Rik, Ccrk
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145349
    NCBI Gene: 105278
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:64580133-64587536 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 33.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    379 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145349
 protein coding gene Chr13:64580128-64589587 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020679
 protein coding gene Chr13:64457415-64464436 (+)
A/J MGP_AJ_G0020633
 protein coding gene Chr13:62120323-62127789 (+)
AKR/J MGP_AKRJ_G0020610
 protein coding gene Chr13:64175381-64183811 (+)
BALB/cJ MGP_BALBcJ_G0020631
 protein coding gene Chr13:62547388-62554422 (+)
C3H/HeJ MGP_C3HHeJ_G0020426
 protein coding gene Chr13:63698238-63705309 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021067
 protein coding gene Chr13:66532740-66540864 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018643
 protein coding gene Chr13:59772658-59779628 (+)
CAST/EiJ MGP_CASTEiJ_G0019943
 protein coding gene Chr13:63721482-63731036 (+)
CBA/J MGP_CBAJ_G0020386
 protein coding gene Chr13:69090436-69101112 (+)
DBA/2J MGP_DBA2J_G0020511
 protein coding gene Chr13:61958270-61965741 (+)
FVB/NJ MGP_FVBNJ_G0020490
 protein coding gene Chr13:61057972-61065915 (+)
LP/J MGP_LPJ_G0020585
 protein coding gene Chr13:64745951-64752998 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020519
 protein coding gene Chr13:68037008-68044164 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021109
 protein coding gene Chr13:63498248-63505809 (+)
PWK/PhJ MGP_PWKPhJ_G0019697
 protein coding gene Chr13:61521284-61528419 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019523
 protein coding gene Chr13:61664594-61671622 (+)
WSB/EiJ MGP_WSBEiJ_G0020003
 protein coding gene Chr13:63980153-63987146 (+)



Homology
more
  • Human Ortholog
    CDK20, cyclin dependent kinase 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK20, cyclin dependent kinase 20
  • Synonyms
    CCRK, CDCH, P42, PNQALRE
  • Links
    NCBI Gene ID: 23552
    neXtProt AC: NX_Q8IZL9
    UniProt: Q8IZL9

  • Chr Location
    9q22.1; chr9:87966441-87974753 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CDK20 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display exencephaly, open neural tubes, cleft palate, absence of the floor plate, achondroplasia of the radius and ulna, and abnormal cilia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    3
  • cDNA Data
    38
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 105278 NCBI Gene Model | MGI Sequence Detail 7404 C57BL/6J ±  kb
    transcript NM_053180 RefSeq | MGI Sequence Detail 1854 Not Specified  
    polypeptide Q9JHU3 UniProt | EBI | MGI Sequence Detail 346 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 38

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145459
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 11
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:354284 Chaya T, et al., Ccrk-Mak/Ick signaling is a ciliary transport regulator essential for retinal photoreceptor survival. Life Sci Alliance. 2024 Nov;7(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory