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Kctd12 Gene Detail
Summary
  • Symbol
    Kctd12
  • Name
    potassium channel tetramerisation domain containing 12
  • Synonyms
    Pfet1, Pfetin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145823
    NCBI Gene: 239217
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:103214017-103220073 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 51.55 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    228 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145823
 protein coding gene Chr14:103214017-103220073 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021626
 protein coding gene Chr14:99461783-99467843 (-)
A/J MGP_AJ_G0021584
 protein coding gene Chr14:96180420-96186474 (-)
AKR/J MGP_AKRJ_G0021560
 protein coding gene Chr14:99057138-99063194 (-)
BALB/cJ MGP_BALBcJ_G0021590
 protein coding gene Chr14:96527446-96533504 (-)
C3H/HeJ MGP_C3HHeJ_G0021368
 protein coding gene Chr14:98952603-98958659 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022030
 protein coding gene Chr14:103483392-103489448 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019570
 protein coding gene Chr14:93054035-93060001 (-)
CAST/EiJ MGP_CASTEiJ_G0020885
 protein coding gene Chr14:96290393-96296396 (-)
CBA/J MGP_CBAJ_G0021336
 protein coding gene Chr14:107189178-107195232 (-)
DBA/2J MGP_DBA2J_G0021460
 protein coding gene Chr14:95661814-95667870 (-)
FVB/NJ MGP_FVBNJ_G0021437
 protein coding gene Chr14:94653497-94659553 (-)
LP/J MGP_LPJ_G0021528
 protein coding gene Chr14:100279944-100285933 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021464
 protein coding gene Chr14:110044213-110051830 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022053
 protein coding gene Chr14:98569657-98575712 (-)
PWK/PhJ MGP_PWKPhJ_G0020628
 protein coding gene Chr14:92670627-92676716 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020466
 protein coding gene Chr14:94618278-94624308 (-)
WSB/EiJ MGP_WSBEiJ_G0020938
 protein coding gene Chr14:99229969-99236053 (-)



Homology
more
  • Human Ortholog
    KCTD12, potassium channel tetramerization domain containing 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCTD12, potassium channel tetramerization domain containing 12
  • Synonyms
    C13orf2, PFET1, PFETIN
  • Links
    NCBI Gene ID: 115207
    neXtProt AC: NX_Q96CX2
    UniProt: Q96CX2

  • Chr Location
    13q22.3; chr13:76880175-76886405 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased fear learning of a discrete auditory-conditioned stimulus, increased activity during the inactive (light) phase and increased intrinsic excitability of pyramidal neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    40
  • cDNA Data
    19
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 239217 NCBI Gene Model | MGI Sequence Detail 6057 C57BL/6J ±  kb
transcript NM_177715 RefSeq | MGI Sequence Detail 6076 C57BL/6  
polypeptide Q6WVG3 UniProt | EBI | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000030477 BTB/POZ domain-containing protein KCTD12
    (term hierarchy)
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR003131 Potassium channel tetramerisation-type BTB domain
    IPR049905 Potassium channel tetramerization domain-containing protein 12, H1 domain
    IPR011333 SKP1/BTB/POZ domain superfamily
  • GlyGen
    Q6WVG3 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 23
    cDNA 19
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145763
References
more
  • Summaries
    All 41
    Developmental Gene Expression 8
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:332917 Ren Y, et al., KCTD8 and KCTD12 Facilitate Axonal Expression of GABA(B) Receptors in Habenula Cholinergic Neurons. J Neurosci. 2022 Mar 2;42(9):1648-1665
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory