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Topors Gene Detail
Summary
  • Symbol
    Topors
  • Name
    topoisomerase I binding, arginine/serine-rich
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146189
    NCBI Gene: 106021
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:40259606-40269841 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 20.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    278 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146189
 protein coding gene Chr4:40259601-40269850 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028142
 protein coding gene Chr4:38112638-38122887 (-)
A/J MGP_AJ_G0028100
 protein coding gene Chr4:36702689-36712939 (-)
AKR/J MGP_AKRJ_G0028063
 protein coding gene Chr4:37598183-37608433 (-)
BALB/cJ MGP_BALBcJ_G0028112
 protein coding gene Chr4:37005524-37015773 (-)
C3H/HeJ MGP_C3HHeJ_G0027840
 protein coding gene Chr4:38168284-38178534 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028553
 protein coding gene Chr4:39556070-39566319 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025894
 protein coding gene Chr4:34401783-34412183 (-)
CAST/EiJ MGP_CASTEiJ_G0027296
 protein coding gene Chr4:37838270-37848499 (-)
CBA/J MGP_CBAJ_G0027812
 protein coding gene Chr4:40887854-40898103 (-)
DBA/2J MGP_DBA2J_G0027956
 protein coding gene Chr4:36613532-36623780 (-)
FVB/NJ MGP_FVBNJ_G0027923
 protein coding gene Chr4:35962416-35972665 (-)
LP/J MGP_LPJ_G0028064
 protein coding gene Chr4:38182363-38192612 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027956
 protein coding gene Chr4:44254455-44264711 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028612
 protein coding gene Chr4:37719894-37730143 (-)
PWK/PhJ MGP_PWKPhJ_G0027014
 protein coding gene Chr4:36600616-36610886 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025757
 protein coding gene Chr3:3701237-3704120 (+)
WSB/EiJ MGP_WSBEiJ_G0027372
 protein coding gene Chr4:37716874-37727145 (-)



Homology
more
  • Human Ortholog
    TOPORS, TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TOPORS, TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  • Synonyms
    LUN, P53BP3, RP31, TP53BPL
  • Links
    NCBI Gene ID: 10210
    neXtProt AC: NX_Q9NS56
    UniProt: Q9NS56

  • Chr Location
    9p21.1; chr9:32540544-32552586 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TOPORS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show a high rate of perinatal lethality, decreased lifespan and decreased weight. MEFs show a high rate of aneuploidy due to a defect in mitotic chromosome segregation. Heterozygotes show increased tumor incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    98
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 106021 NCBI Gene Model | MGI Sequence Detail 10236 C57BL/6J ±  kb
    transcript NM_134097 RefSeq | MGI Sequence Detail 3842 Not Specified  
    polypeptide Q80Z37 UniProt | EBI | MGI Sequence Detail 1033 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      cDNA 98

      Microarray probesets 6
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory