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Otub1 Gene Detail
Summary
  • Symbol
    Otub1
  • Name
    OTU domain, ubiquitin aldehyde binding 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147616
    NCBI Gene: 107260
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:7175571-7183649 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.27 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    231 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147616
 protein coding gene Chr19:7175567-7183681 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024785
 protein coding gene Chr19:4314088-4323490 (-)
A/J MGP_AJ_G0024752
 protein coding gene Chr19:3965860-3973783 (-)
AKR/J MGP_AKRJ_G0024725
 protein coding gene Chr19:4100244-4108147 (-)
BALB/cJ MGP_BALBcJ_G0024752
 protein coding gene Chr19:4085507-4093396 (-)
C3H/HeJ MGP_C3HHeJ_G0024520
 protein coding gene Chr19:4225864-4233795 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025198
 protein coding gene Chr19:4402231-4410164 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022632
 protein coding gene Chr19:3872205-3877911 (-)
CAST/EiJ MGP_CASTEiJ_G0023992
 protein coding gene Chr19:4132767-4140696 (-)
CBA/J MGP_CBAJ_G0024492
 protein coding gene Chr19:4479735-4487660 (-)
DBA/2J MGP_DBA2J_G0024619
 protein coding gene Chr19:3935807-3943740 (-)
FVB/NJ MGP_FVBNJ_G0024584
 protein coding gene Chr19:3972550-3981875 (-)
LP/J MGP_LPJ_G0024705
 protein coding gene Chr19:4169679-4185789 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024614
 protein coding gene Chr19:4366070-4374002 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025246
 protein coding gene Chr19:4242710-4250633 (-)
PWK/PhJ MGP_PWKPhJ_G0023738
 protein coding gene Chr19:3985315-4003507 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023542
 protein coding gene Chr19:4043664-4051979 (-)
WSB/EiJ MGP_WSBEiJ_G0024054
 protein coding gene Chr19:4140861-4148783 (-)



Homology
more
  • Human Ortholog
    OTUB1, OTU deubiquitinase, ubiquitin aldehyde binding 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OTUB1, OTU deubiquitinase, ubiquitin aldehyde binding 1
  • Synonyms
    HSPC263, OTB1, OTU1
  • Links
    NCBI Gene ID: 55611
    neXtProt AC: NX_Q96FW1
    UniProt: Q96FW1

  • Chr Location
    11q13.1; chr11:63985853-64001811 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die between E14.5 and birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    85
  • cDNA Data
    11
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107260 NCBI Gene Model | MGI Sequence Detail 8079 C57BL/6J ±  kb
    transcript NM_134150 RefSeq | MGI Sequence Detail 1677 C57BL/6  
    polypeptide Q7TQI3 UniProt | EBI | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 4
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345930 Luo VM, et al., The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the gamma-Subunit Gng2. Mol Cell Biol. 2024 Jan;44(1):1-16
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory