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Pcyt1b Gene Detail
Summary
  • Symbol
    Pcyt1b
  • Name
    phosphate cytidylyltransferase 1, choline, beta isoform
  • Synonyms
    CTTbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147987
    NCBI Gene: 236899
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:92698469-92793557 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 41.28 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1713 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147987
 protein coding gene ChrX:92698469-92793557 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035904
 protein coding gene ChrX:90024938-90116048 (+)
A/J MGP_AJ_G0035890
 protein coding gene ChrX:90124841-90218393 (+)
AKR/J MGP_AKRJ_G0035807
 protein coding gene ChrX:92495125-92590778 (+)
BALB/cJ MGP_BALBcJ_G0035874
 protein coding gene ChrX:88820647-88912947 (+)
C3H/HeJ MGP_C3HHeJ_G0035583
 protein coding gene ChrX:90391102-90481786 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036403
 protein coding gene ChrX:92777666-92869561 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033230
 protein coding gene ChrX:88301165-88393183 (+)
CAST/EiJ MGP_CASTEiJ_G0034868
 protein coding gene ChrX:75056695-75150018 (+)
CBA/J MGP_CBAJ_G0035557
 protein coding gene ChrX:95467004-95561352 (+)
DBA/2J MGP_DBA2J_G0035713
 protein coding gene ChrX:89374832-89468392 (+)
FVB/NJ MGP_FVBNJ_G0035652
 protein coding gene ChrX:88764965-88861971 (+)
LP/J MGP_LPJ_G0035801
 protein coding gene ChrX:90808861-90905179 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035686
 protein coding gene ChrX:99750948-99850571 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036430
 protein coding gene ChrX:89744701-89834551 (+)
PWK/PhJ MGP_PWKPhJ_G0034567
 protein coding gene ChrX:72855926-72947208 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034397
 protein coding gene ChrX:75905325-76009422 (+)
WSB/EiJ MGP_WSBEiJ_G0035009
 protein coding gene ChrX:88538578-88637408 (+)



Homology
more
  • Human Ortholog
    PCYT1B, phosphate cytidylyltransferase 1B, choline
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCYT1B, phosphate cytidylyltransferase 1B, choline
  • Synonyms
    CCTB, CTB
  • Links
    NCBI Gene ID: 9468
    neXtProt AC: NX_Q9Y5K3
    UniProt: Q9Y5K3

  • Chr Location
    Xp22.11; chrX:24558087-24672887 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice reduced fertility, abnormal ovaries with absent corpora lutea and follicles, benign ovarian tumors, seminiferous tubule degeneration, and reduced spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1094
  • Tissues
    189
  • cDNA Data
    71
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 236899 NCBI Gene Model | MGI Sequence Detail 95089 C57BL/6J ±  kb
    transcript NM_211138 RefSeq | MGI Sequence Detail 4875 Not Specified  
    polypeptide Q811Q9 UniProt | EBI | MGI Sequence Detail 369 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 71
      Primer pair 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:84309 Karim M, et al., Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase beta isoform. Biochim Biophys Acta. 2003 Jul 4;1633(1):1-12
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory