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Mta1 Gene Detail
Summary
  • Symbol
    Mta1
  • Name
    metastasis associated 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150037
    NCBI Gene: 116870
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:113061898-113100826 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.57 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    190 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150037
 protein coding gene Chr12:113061830-113100826 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020171
 protein coding gene Chr12:115592924-115633257 (+)
A/J MGP_AJ_G0020127
 protein coding gene Chr12:111116819-111155407 (+)
AKR/J MGP_AKRJ_G0020102
 protein coding gene Chr12:114347997-114386620 (+)
BALB/cJ MGP_BALBcJ_G0020112
 protein coding gene Chr12:111559300-111620922 (+)
C3H/HeJ MGP_C3HHeJ_G0019914
 protein coding gene Chr12:114871128-114908564 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020557
 protein coding gene Chr12:119141486-119178646 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018171
 protein coding gene Chr12:107551065-107588742 (+)
CAST/EiJ MGP_CASTEiJ_G0019454
 protein coding gene Chr12:109706751-109752926 (+)
CBA/J MGP_CBAJ_G0019881
 protein coding gene Chr12:123678289-123746637 (+)
DBA/2J MGP_DBA2J_G0019998
 protein coding gene Chr12:110617749-110656527 (+)
FVB/NJ MGP_FVBNJ_G0019983
 protein coding gene Chr12:109433009-109500144 (+)
LP/J MGP_LPJ_G0020072
 protein coding gene Chr12:115412140-115453591 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020021
 protein coding gene Chr12:126792111-126833202 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020586
 protein coding gene Chr12:113862929-113903323 (+)
PWK/PhJ MGP_PWKPhJ_G0019216
 protein coding gene Chr12:105252006-105318235 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019020
 protein coding gene Chr12:108016675-108083314 (+)
WSB/EiJ MGP_WSBEiJ_G0019514
 protein coding gene Chr12:114777364-114817565 (+)



Homology
more
  • Human Ortholog
    MTA1, metastasis associated 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTA1, metastasis associated 1
  • Links
    NCBI Gene ID: 9112
    neXtProt AC: NX_Q13330
    UniProt: Q13330

  • Chr Location
    14q32.33; chr14:105419820-105470729 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 5 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased cellular sensitivity to ionizing radiation and increased retinal cell proliferation at E14.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    81
  • cDNA Data
    101
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021144 Ensembl Gene Model | MGI Sequence Detail 38929 C57BL/6J ±  kb
    transcript ENSMUST00000009099 Ensembl | MGI Sequence Detail 2826 Not Applicable  
    polypeptide ENSMUSP00000009099 Ensembl | MGI Sequence Detail 715 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      Genomic 1
      cDNA 101
      Primer pair 4
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 13
      Gene Ontology 24
      Phenotypes 27
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory