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Slc4a10 Gene Detail
Summary
  • Symbol
    Slc4a10
  • Name
    solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
  • Synonyms
    NCBE
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150150
    NCBI Gene: 94229
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:61876806-62157074 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 35.79 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6804 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150150
 protein coding gene Chr2:61876806-62157087 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025768
 protein coding gene Chr2:61707227-62007217 (+)
A/J MGP_AJ_G0025744
 protein coding gene Chr2:59358269-59633717 (+)
AKR/J MGP_AKRJ_G0025714
 protein coding gene Chr2:60956712-61231856 (+)
BALB/cJ MGP_BALBcJ_G0025739
 protein coding gene Chr2:59456544-59734573 (+)
C3H/HeJ MGP_C3HHeJ_G0025500
 protein coding gene Chr2:61058312-61338209 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026186
 protein coding gene Chr2:63544864-63830185 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023590
 protein coding gene Chr2:57053791-57154221 (+)
CAST/EiJ MGP_CASTEiJ_G0024964
 protein coding gene Chr2:61113077-61405771 (+)
CBA/J MGP_CBAJ_G0025480
 protein coding gene Chr2:65931683-66245882 (+)
DBA/2J MGP_DBA2J_G0025611
 protein coding gene Chr2:58936184-59213893 (+)
FVB/NJ MGP_FVBNJ_G0025573
 protein coding gene Chr2:58463307-58734336 (+)
LP/J MGP_LPJ_G0025699
 protein coding gene Chr2:61552710-61836929 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025604
 protein coding gene Chr2:67567434-67939893 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026243
 protein coding gene Chr2:61004234-61299686 (+)
PWK/PhJ MGP_PWKPhJ_G0024705
 protein coding gene Chr2:58798405-59077618 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024512
 protein coding gene Chr2:61118713-61399077 (+)
WSB/EiJ MGP_WSBEiJ_G0025032
 protein coding gene Chr2:61336319-61614208 (+)



Homology
more
  • Human Ortholog
    SLC4A10, solute carrier family 4 member 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC4A10, solute carrier family 4 member 10
  • Synonyms
    NBCn2, NCBE
  • Links
    NCBI Gene ID: 57282
    neXtProt AC: NX_Q6U841
    UniProt: Q6U841

  • Chr Location
    2q24.2; chr2:161424332-161985282 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with homozygous disruption of this gene exhibit reduced brain ventricle volume, reduced neuronal excitability, impaired pH regulation of neurons, and increased threshold to induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1026
  • Tissues
    205
  • cDNA Data
    32
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026904 Ensembl Gene Model | MGI Sequence Detail 280269 C57BL/6J ±  kb
    transcript ENSMUST00000112480 Ensembl | MGI Sequence Detail 5389 Not Applicable  
    polypeptide ENSMUSP00000108099 Ensembl | MGI Sequence Detail 1118 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000015155 sodium-driven chloride bicarbonate exchanger
      (term hierarchy)
    • InterPro Domains
      IPR013769 Band 3 cytoplasmic domain
      IPR003020 Bicarbonate transporter, eukaryotic
      IPR011531 Bicarbonate transporter-like, transmembrane domain
      IPR016152 Phosphotransferase/anion transporter
      IPR003024 Sodium bicarbonate cotransporter
    • GlyGen
      Q5DTL9 4 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 33
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 13
      Gene Ontology 18
      Phenotypes 21
    • Earliest
      J:70983 Wang CZ, et al., The Na+-driven Cl-/HCO3- exchanger. Cloning, tissue distribution, and functional characterization. J Biol Chem. 2000 Nov 10;275(45):35486-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory