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Dscaml1 Gene Detail
Summary
  • Symbol
    Dscaml1
  • Name
    DS cell adhesion molecule like 1
  • Synonyms
    4921507G06Rik, 4930435C18Rik, mKIAA1132
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150309
    NCBI Gene: 114873
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45338735-45665011 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9030 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150309
 protein coding gene Chr9:45337926-45665011 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034739
 protein coding gene Chr9:43990838-44334775 (+)
A/J MGP_AJ_G0034720
 protein coding gene Chr9:42764821-43095246 (+)
AKR/J MGP_AKRJ_G0034647
 protein coding gene Chr9:43640911-43975332 (+)
BALB/cJ MGP_BALBcJ_G0034711
 protein coding gene Chr9:42491144-42818538 (+)
C3H/HeJ MGP_C3HHeJ_G0034422
 protein coding gene Chr9:44097254-44433259 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035232
 protein coding gene Chr9:45276974-45623008 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032146
 protein coding gene Chr9:42309674-42633373 (+)
CAST/EiJ MGP_CASTEiJ_G0033744
 protein coding gene Chr9:43957678-44295708 (+)
CBA/J MGP_CBAJ_G0034394
 protein coding gene Chr9:46936274-47293696 (+)
DBA/2J MGP_DBA2J_G0034553
 protein coding gene Chr9:42645879-42970733 (+)
FVB/NJ MGP_FVBNJ_G0034494
 protein coding gene Chr9:41908563-42236715 (+)
LP/J MGP_LPJ_G0034634
 protein coding gene Chr9:44295431-44660718 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034538
 protein coding gene Chr9:48737224-49068443 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035253
 protein coding gene Chr9:43563193-43889167 (+)
PWK/PhJ MGP_PWKPhJ_G0033449
 protein coding gene Chr9:42536404-42872491 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033285
 protein coding gene Chr9:43859769-44210829 (+)
WSB/EiJ MGP_WSBEiJ_G0033857
 protein coding gene Chr9:43592578-43939788 (+)



Homology
more
  • Human Ortholog
    DSCAML1, DS cell adhesion molecule like 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DSCAML1, DS cell adhesion molecule like 1
  • Synonyms
    DSCAM2
  • Links
    NCBI Gene ID: 57453
    neXtProt AC: NX_Q8TD84
    UniProt: Q8TD84

  • Chr Location
    11q23.3; chr11:117427772-117817525 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit impaired self-avoidance in multiple cell types in the retina.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    860
  • Tissues
    68
  • cDNA Data
    42
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114873 NCBI Gene Model | MGI Sequence Detail 326277 C57BL/6J ±  kb
    transcript NM_001081270 RefSeq | MGI Sequence Detail 6825 C57BL/6  
    polypeptide Q4VA61 UniProt | EBI | MGI Sequence Detail 2053 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 46
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918065, MGI:1921906, MGI:2143375
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:342562 Clemons MR, et al., The rod synapse in aging wildtype and Dscaml1 mutant mice. PLoS One. 2023;18(11):e0290257
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory