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Srd5a2 Gene Detail
Summary
  • Symbol
    Srd5a2
  • Name
    steroid 5 alpha-reductase 2
  • Synonyms
    5ART2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150380
    NCBI Gene: 94224
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:74323950-74354911 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 45.39 cM, cytoband E2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    918 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150380
 protein coding gene Chr17:74321886-74354911 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024023
 protein coding gene Chr17:76608655-76640363 (-)
A/J MGP_AJ_G0023981
 protein coding gene Chr17:74279170-74309895 (-)
AKR/J MGP_AKRJ_G0023950
 protein coding gene Chr17:75336550-75366301 (-)
BALB/cJ MGP_BALBcJ_G0023982
 protein coding gene Chr17:74183087-74215168 (-)
C3H/HeJ MGP_C3HHeJ_G0023746
 protein coding gene Chr17:76272222-76305613 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024428
 protein coding gene Chr17:79383528-79415780 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021872
 protein coding gene Chr17:69946387-69975043 (-)
CAST/EiJ MGP_CASTEiJ_G0023227
 protein coding gene Chr17:76751030-76783605 (-)
CBA/J MGP_CBAJ_G0023721
 protein coding gene Chr17:82674633-82710424 (-)
DBA/2J MGP_DBA2J_G0023850
 protein coding gene Chr17:72884215-72913816 (-)
FVB/NJ MGP_FVBNJ_G0023816
 protein coding gene Chr17:72380702-72410312 (-)
LP/J MGP_LPJ_G0023932
 protein coding gene Chr17:77373175-77404871 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023844
 protein coding gene Chr17:82477096-82509457 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024472
 protein coding gene Chr17:75829815-75859476 (-)
PWK/PhJ MGP_PWKPhJ_G0022973
 protein coding gene Chr17:72247929-72277657 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022784
 protein coding gene Chr17:72503251-72538842 (-)
WSB/EiJ MGP_WSBEiJ_G0023294
 protein coding gene Chr17:76683850-76714732 (-)



Homology
more
  • Human Ortholog
    SRD5A2, steroid 5 alpha-reductase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRD5A2, steroid 5 alpha-reductase 2
  • Links
    NCBI Gene ID: 6716
    neXtProt AC: NX_P31213
    UniProt: P31213

  • Chr Location
    2p23.1; chr2:31522480-31663009 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SRD5A2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutant males are fertile, but have small prostates and seminal vesicles, elevated testosterone in reproductive tissue and decreased androgen-dependent gene expression. Mutant females exhibit no detectable abnormality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1136
  • Tissues
    322
  • cDNA Data
    7
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038541 Ensembl Gene Model | MGI Sequence Detail 30962 C57BL/6J ±  kb
    transcript ENSMUST00000043458 Ensembl | MGI Sequence Detail 1605 Not Applicable  
    polypeptide ENSMUSP00000048862 Ensembl | MGI Sequence Detail 254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000015608 3-oxo-5-alpha-steroid 4-dehydrogenase 2
      (term hierarchy)
    • EC
      1.3.1.22
    • InterPro Domains
      IPR016636 3-oxo-5-alpha-steroid 4-dehydrogenase
      IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
      IPR039357 3-oxo-5-alpha-steroid 4-dehydrogenase/very-long-chain enoyl-CoA reductase
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 12
    • Earliest
      J:72807 Mahendroo MS, et al., Unexpected virilization in male mice lacking steroid 5alpha-reductase enzymes. Endocrinology. 2001 Nov;142(11):4652-62
    • Latest
      J:356607 Sharkey C, et al., Enhanced prostatic Esr1(+) luminal epithelial cells in the absence of SRD5A2. J Pathol. 2024 Jul;263(3):300-314
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory