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Pop5 Gene Detail
Summary
  • Symbol
    Pop5
  • Name
    processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)
  • Synonyms
    1500019J17Rik, 2700077E03Rik, Rnasep3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151221
    NCBI Gene: 117109
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:115373505-115379031 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.01 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151221
 protein coding gene Chr5:115373505-115383410 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029961
 protein coding gene Chr5:118080564-118090728 (+)
A/J MGP_AJ_G0029926
 protein coding gene Chr5:113402801-113412320 (+)
AKR/J MGP_AKRJ_G0029864
 protein coding gene Chr5:117032949-117044137 (+)
BALB/cJ MGP_BALBcJ_G0029937
 protein coding gene Chr5:114799650-114809148 (+)
C3H/HeJ MGP_C3HHeJ_G0029656
 protein coding gene Chr5:117541393-117550928 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030391
 protein coding gene Chr5:122643452-122654458 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027618
 protein coding gene Chr5:108174720-108184872 (+)
CAST/EiJ MGP_CASTEiJ_G0029065
 protein coding gene Chr5:116459526-116468905 (+)
CBA/J MGP_CBAJ_G0029624
 protein coding gene Chr5:127350531-127360066 (+)
DBA/2J MGP_DBA2J_G0029774
 protein coding gene Chr5:113473907-113483432 (+)
FVB/NJ MGP_FVBNJ_G0029730
 protein coding gene Chr5:112290526-112300061 (+)
LP/J MGP_LPJ_G0029862
 protein coding gene Chr5:118657983-118667493 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029761
 protein coding gene Chr5:131675600-131685351 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030432
 protein coding gene Chr5:116497736-116507258 (+)
PWK/PhJ MGP_PWKPhJ_G0028778
 protein coding gene Chr5:112136769-112146330 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028616
 protein coding gene Chr5:114053223-114063639 (+)
WSB/EiJ MGP_WSBEiJ_G0029140
 protein coding gene Chr5:117094700-117104225 (+)



Homology
more
  • Human Ortholog
    POP5, POP5 homolog, ribonuclease P/MRP subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POP5, POP5 homolog, ribonuclease P/MRP subunit
  • Synonyms
    hPop5, HSPC004, RPP2, RPP20
  • Links
    NCBI Gene ID: 51367
    neXtProt AC: NX_Q969H6
    UniProt: Q969H6

  • Chr Location
    12q24.31; chr12:120578764-120581402 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show failure of morula compaction and embryonic lethality before implantation. In vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming blastocysts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    849
  • Tissues
    16
  • cDNA Data
    36
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 117109 NCBI Gene Model | MGI Sequence Detail 5527 C57BL/6J ±  kb
transcript NM_026398 RefSeq | MGI Sequence Detail 1340 C57BL/6  
polypeptide Q9DB28 UniProt | EBI | MGI Sequence Detail 169 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013026 ribonuclease P/MRP protein subunit POP5
    (term hierarchy)
  • InterPro Domains
    IPR052312 Eukaryotic/Archaeal RNase P Protein Component 2
    IPR016819 Ribonuclease P/MRP protein subunit Pop5
    IPR002759 RNase P subunit Pop5/Rpp14/Rnp2-like
    IPR038085 RNase P subunit Pop5/Rpp14/Rnp2-like domain superfamily
Molecular
Reagents
less
  • All nucleic 36
    cDNA 36

    Microarray probesets 4
Other
Accession IDs
less
MGI:1915085, MGI:1919879, MGI:2141138
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory