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Ngb Gene Detail
Summary
  • Symbol
    Ngb
  • Name
    neuroglobin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151886
    NCBI Gene: 64242
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr12:87144305-87149313 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 41.29 cM, cytoband D3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    204 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151886
 protein coding gene Chr12:87144305-87149313 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019977
 protein coding gene Chr12:87989254-87994251 (-)
A/J MGP_AJ_G0019935
 protein coding gene Chr12:84644865-84649869 (-)
AKR/J MGP_AKRJ_G0019910
 protein coding gene Chr12:86938859-86945597 (-)
BALB/cJ MGP_BALBcJ_G0019914
 protein coding gene Chr12:84977153-84982701 (-)
C3H/HeJ MGP_C3HHeJ_G0019720
 protein coding gene Chr12:87426598-87432515 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020366
 protein coding gene Chr12:90522248-90527736 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017984
 protein coding gene Chr12:81530030-81535092 (-)
CAST/EiJ MGP_CASTEiJ_G0019270
 protein coding gene Chr12:82450699-82455910 (-)
CBA/J MGP_CBAJ_G0019692
 protein coding gene Chr12:94005668-94012291 (-)
DBA/2J MGP_DBA2J_G0019805
 protein coding gene Chr12:84132387-84137465 (-)
FVB/NJ MGP_FVBNJ_G0019792
 protein coding gene Chr12:83129360-83134364 (-)
LP/J MGP_LPJ_G0019879
 protein coding gene Chr12:87866984-87871957 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019831
 protein coding gene Chr12:96748111-96753178 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020398
 protein coding gene Chr12:86567788-86574565 (-)
PWK/PhJ MGP_PWKPhJ_G0019034
 protein coding gene Chr12:78690555-78695897 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018829
 protein coding gene Chr12:81060289-81065341 (-)
WSB/EiJ MGP_WSBEiJ_G0019323
 protein coding gene Chr12:87341599-87346697 (-)



Homology
more
  • Human Ortholog
    NGB, neuroglobin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NGB, neuroglobin
  • Links
    NCBI Gene ID: 58157
    neXtProt AC: NX_Q9NPG2
    UniProt: Q9NPG2

  • Chr Location
    14q24.3; chr14:77265483-77271206 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a significantly larger phase delay of circadian rhythm upon light stimulation at early night.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    15
  • cDNA Data
    10
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 64242 NCBI Gene Model | MGI Sequence Detail 5009 C57BL/6J ±  kb
transcript NM_001294308 RefSeq | MGI Sequence Detail 1644 C57BL/6  
polypeptide Q9ER97 UniProt | EBI | MGI Sequence Detail 151 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 10
    Primer pair 2
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 73
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 21
  • Earliest
    J:64988 Burmester T, et al., A vertebrate globin expressed in the brain. Nature. 2000 Sep 28;407(6803):520-3
  • Latest
    J:327067 Shang L, et al., Neuroglobin Is Involved in the Hypoxic Stress Response in the Brain. Biomed Res Int. 2022;2022:8263373
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory