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Pip4k2c Gene Detail
Summary
  • Symbol
    Pip4k2c
  • Name
    phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
  • Synonyms
    Pip5k2c
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152214
    NCBI Gene: 117150
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127032936-127047454 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.50 cM, cytoband D3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    352 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152214
 protein coding gene Chr10:127032936-127047508 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017812
 protein coding gene Chr10:130780524-130795097 (-)
A/J MGP_AJ_G0017787
 protein coding gene Chr10:125542243-125556729 (-)
AKR/J MGP_AKRJ_G0017750
 protein coding gene Chr10:129257016-129271593 (-)
BALB/cJ MGP_BALBcJ_G0017751
 protein coding gene Chr10:125953159-125967714 (-)
C3H/HeJ MGP_C3HHeJ_G0017575
 protein coding gene Chr10:129399988-129414538 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018206
 protein coding gene Chr10:135216066-135230642 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015886
 protein coding gene Chr10:119550237-119563786 (-)
CAST/EiJ MGP_CASTEiJ_G0017135
 protein coding gene Chr10:130054074-130072052 (-)
CBA/J MGP_CBAJ_G0017544
 protein coding gene Chr10:140657049-140672316 (-)
DBA/2J MGP_DBA2J_G0017650
 protein coding gene Chr10:124635167-124649637 (-)
FVB/NJ MGP_FVBNJ_G0017645
 protein coding gene Chr10:123575163-123589685 (-)
LP/J MGP_LPJ_G0017724
 protein coding gene Chr10:131351649-131366235 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017673
 protein coding gene Chr10:143369434-143383956 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018246
 protein coding gene Chr10:129319275-129333824 (-)
PWK/PhJ MGP_PWKPhJ_G0016920
 protein coding gene Chr10:124831405-124845958 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016712
 protein coding gene Chr10:128353721-128368047 (-)
WSB/EiJ MGP_WSBEiJ_G0017196
 protein coding gene Chr10:129544448-129558991 (-)



Homology
more
  • Human Ortholog
    PIP4K2C, phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIP4K2C, phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
  • Synonyms
    PIP5K2C
  • Links
    NCBI Gene ID: 79837
    neXtProt AC: NX_Q8TBX8
    UniProt: Q8TBX8

  • Chr Location
    12q13.3; chr12:57591174-57603418 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 1 allele in 2 genetic backgrounds
    3 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele develop enhanced immune responses associated with T cell hyperactivation, increased T cell proliferation, increased immune infiltrates in various tissues, increased plasma cytokine levels, and increased mTORC1 signaling.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    933
  • Tissues
    175
  • cDNA Data
    126
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025417 Ensembl Gene Model | MGI Sequence Detail 14519 C57BL/6J ±  kb
    transcript ENSMUST00000013970 Ensembl | MGI Sequence Detail 3307 Not Applicable  
    polypeptide ENSMUSP00000013970 Ensembl | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000012743 phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
      (term hierarchy)
    • EC
      2.7.1.149
    • InterPro Domains
      IPR023610 Phosphatidylinositol-4/5-phosphate 5/4-kinase
      IPR002498 Phosphatidylinositol-4-phosphate 4/5-kinase, core
      IPR027483 Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily
      IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
    • GlyGen
      Q91XU3 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 130
      cDNA 127
      Primer pair 1
      Other 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:75718 Akiba Y, et al., Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development. Brain Res Gene Expr Patterns. 2002 Jan;1(2):123-33
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory