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Rims2 Gene Detail
Summary
  • Symbol
    Rims2
  • Name
    regulating synaptic membrane exocytosis 2
  • Synonyms
    2810036I15Rik, mKIAA0751, RIM2, Syt3-rs
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152972
    NCBI Gene: 116838
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:39061681-39547768 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 15.45 cM, cytoband C
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12519 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152972
 protein coding gene Chr15:39061656-39547768 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021815
 protein coding gene Chr15:37621254-38149336 (+)
A/J MGP_AJ_G0021775
 protein coding gene Chr15:36171498-36654274 (+)
AKR/J MGP_AKRJ_G0021756
 protein coding gene Chr15:37248455-37752668 (+)
BALB/cJ MGP_BALBcJ_G0021782
 protein coding gene Chr15:36205711-36710307 (+)
C3H/HeJ MGP_C3HHeJ_G0021556
 protein coding gene Chr15:37170709-37669087 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022221
 protein coding gene Chr15:39059196-39593369 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019758
 protein coding gene Chr15:33915935-34398307 (+)
CAST/EiJ MGP_CASTEiJ_G0021073
 protein coding gene Chr15:37616087-38133837 (+)
CBA/J MGP_CBAJ_G0021525
 protein coding gene Chr15:40433347-41019332 (+)
DBA/2J MGP_DBA2J_G0021649
 protein coding gene Chr15:35994725-36487972 (+)
FVB/NJ MGP_FVBNJ_G0021627
 protein coding gene Chr15:35397229-35878805 (+)
LP/J MGP_LPJ_G0021719
 protein coding gene Chr15:37484458-37961996 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021651
 protein coding gene Chr15:43296860-44023102 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022244
 protein coding gene Chr15:37383969-37896684 (+)
PWK/PhJ MGP_PWKPhJ_G0020818
 protein coding gene Chr15:36057314-36556066 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020655
 protein coding gene Chr15:37069355-37591635 (+)
WSB/EiJ MGP_WSBEiJ_G0021128
 protein coding gene Chr15:37309575-37826099 (+)



Homology
more
  • Human Ortholog
    RIMS2, regulating synaptic membrane exocytosis 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RIMS2, regulating synaptic membrane exocytosis 2
  • Synonyms
    CRSDS, OBOE, RAB3IP3, RIM2
  • Links
    NCBI Gene ID: 9699
    neXtProt AC: NX_Q9UQ26
    UniProt: Q9UQ26

  • Chr Location
    8q22.3; chr8:103500610-104256094 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show reduced body size, aberrant insulin granule exocytosis, and impaired secretion of hormones associated with glucose homeostasis. Mice homozygous for another knock-out allele show a slightly reduced body size, abnormal maternal behavior and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    9
  • cDNA Data
    4
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 116838 NCBI Gene Model | MGI Sequence Detail 486088 C57BL/6J ±  kb
    transcript NM_001256382 RefSeq | MGI Sequence Detail 7404 ZRU/MplStud  
    polypeptide Q9EQZ7 UniProt | EBI | MGI Sequence Detail 1530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 7
      Primer pair 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36375, MGI:107798, MGI:1919910, MGI:2146180
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 7
      Gene Ontology 20
      Phenotypes 46
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:358058 Emperador-Melero J, et al., Distinct active zone protein machineries mediate Ca(2+) channel clustering and vesicle priming at hippocampal synapses. Nat Neurosci. 2024 Sep;27(9):1680-1694
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory