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Cspg4 Gene Detail
Summary
  • Symbol
    Cspg4
  • Name
    chondroitin sulfate proteoglycan 4
  • Synonyms
    4732461B14Rik, AN2, Cspg4a, NG2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153093
    NCBI Gene: 121021
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:56772388-56807154 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 30.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    803 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153093
 protein coding gene Chr9:56772317-56807154 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034853
 protein coding gene Chr9:56023344-56058106 (+)
A/J MGP_AJ_G0034834
 protein coding gene Chr9:54218647-54253420 (+)
AKR/J MGP_AKRJ_G0034763
 protein coding gene Chr9:55474900-55509645 (+)
BALB/cJ MGP_BALBcJ_G0034826
 protein coding gene Chr9:54014843-54049636 (+)
C3H/HeJ MGP_C3HHeJ_G0034536
 protein coding gene Chr9:55938039-55972769 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035345
 protein coding gene Chr9:57596070-57630831 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032256
 protein coding gene Chr9:53558397-53593074 (+)
CAST/EiJ MGP_CASTEiJ_G0033857
 protein coding gene Chr9:56007352-56042029 (+)
CBA/J MGP_CBAJ_G0034507
 protein coding gene Chr9:59582276-59617037 (+)
DBA/2J MGP_DBA2J_G0034666
 protein coding gene Chr9:54102997-54137754 (+)
FVB/NJ MGP_FVBNJ_G0034608
 protein coding gene Chr9:53321113-53356880 (+)
LP/J MGP_LPJ_G0034749
 protein coding gene Chr9:56310541-56345333 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034651
 protein coding gene Chr9:61082073-61118115 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035367
 protein coding gene Chr9:55477346-55512090 (+)
PWK/PhJ MGP_PWKPhJ_G0033561
 protein coding gene Chr9:54084282-54169880 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033396
 protein coding gene Chr9:55757984-55797430 (+)
WSB/EiJ MGP_WSBEiJ_G0033970
 protein coding gene Chr9:55415952-55450820 (+)



Homology
more
  • Human Ortholog
    CSPG4, chondroitin sulfate proteoglycan 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSPG4, chondroitin sulfate proteoglycan 4
  • Synonyms
    CSPG4A, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
  • Links
    NCBI Gene ID: 1464
    neXtProt AC: NX_Q6UVK1
    UniProt: Q6UVK1

  • Chr Location
    15q24.2; chr15:75674322-75713466 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CSPG4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 4 alleles in 5 genetic backgrounds
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display abnormal dentate gyrus morphology and abnormal smooth muscle cell physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1071
  • Tissues
    128
  • cDNA Data
    47
  • Literature Summary
    249
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 121021 NCBI Gene Model | MGI Sequence Detail 34767 C57BL/6J ±  kb
    transcript NM_139001 RefSeq | MGI Sequence Detail 8050 C57BL/6  
    polypeptide Q8VHY0 UniProt | EBI | MGI Sequence Detail 2327 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005953 chondroitin sulfate proteoglycan 4
      (term hierarchy)
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR039005 CSPG repeat
      IPR051561 FRAS1-related extracellular matrix
      IPR001791 Laminin G domain
    • GlyGen
      Q8VHY0 17 sites, 4 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 47
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2443606
    References
    more
    • Summaries
      All 366
      Developmental Gene Expression 249
      Gene Ontology 12
      Phenotypes 72
    • Earliest
      J:54319 Grako KA, et al., PDGF (alpha)-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse. J Cell Sci. 1999 Mar;112(Pt 6):905-15
    • Latest
      J:358092 Pivonkova H, et al., Heterogeneity in oligodendrocyte precursor cell proliferation is dynamic and driven by passive bioelectrical properties. Cell Rep. 2024 Oct 16;43(11):114873
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory