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Tmprss3 Gene Detail
Summary
  • Symbol
    Tmprss3
  • Name
    transmembrane protease, serine 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155445
    NCBI Gene: 140765
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:31398239-31417951 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    708 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155445
 protein coding gene Chr17:31398237-31419478 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023484
 protein coding gene Chr17:30918944-30938702 (-)
A/J MGP_AJ_G0023442
 protein coding gene Chr17:29909963-29929668 (-)
AKR/J MGP_AKRJ_G0023407
 protein coding gene Chr17:30156682-30176388 (-)
BALB/cJ MGP_BALBcJ_G0023447
 protein coding gene Chr17:30017870-30037628 (-)
C3H/HeJ MGP_C3HHeJ_G0023208
 protein coding gene Chr17:30540502-30560206 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023889
 protein coding gene Chr17:31987365-32007068 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021363
 protein coding gene Chr17:27049751-27069427 (-)
CAST/EiJ MGP_CASTEiJ_G0022709
 protein coding gene Chr17:30567870-30587617 (-)
CBA/J MGP_CBAJ_G0023183
 protein coding gene Chr17:33411693-33431398 (-)
DBA/2J MGP_DBA2J_G0023313
 protein coding gene Chr17:29327817-29347575 (-)
FVB/NJ MGP_FVBNJ_G0023283
 protein coding gene Chr17:29111470-29131187 (-)
LP/J MGP_LPJ_G0023391
 protein coding gene Chr17:31140422-31160180 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023301
 protein coding gene Chr17:32476530-32496174 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023931
 protein coding gene Chr17:30529593-30549279 (-)
PWK/PhJ MGP_PWKPhJ_G0022459
 protein coding gene Chr17:28143244-28162925 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022277
 protein coding gene Chr17:28516805-28536463 (-)
WSB/EiJ MGP_WSBEiJ_G0022771
 protein coding gene Chr17:30488384-30508091 (-)



Homology
more
  • Human Ortholog
    TMPRSS3, transmembrane serine protease 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMPRSS3, transmembrane serine protease 3
  • Synonyms
    DFNB10, DFNB8, ECHOS1, TADG12
  • Links
    NCBI Gene ID: 64699
    neXtProt AC: NX_P57727
    UniProt: P57727

  • Chr Location
    21q22.3; chr21:42371887-42396091 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TMPRSS3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    6 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit early onset deafness and disrupted vestibular function associated with hair cell degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    79
  • cDNA Data
    9
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024034 Ensembl Gene Model | MGI Sequence Detail 19713 C57BL/6J ±  kb
    transcript ENSMUST00000114549 Ensembl | MGI Sequence Detail 2881 Not Applicable  
    polypeptide ENSMUSP00000110196 Ensembl | MGI Sequence Detail 475 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 9
      Primer pair 5
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 5
      Diseases 3
      Gene Ontology 6
      Phenotypes 34
    • Earliest
      J:69673 Davisson MT, et al., Evolutionary breakpoints on human chromosome 21. Genomics. 2001 Nov;78(1/2):99-106
    • Latest
      J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory