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Dppa2 Gene Detail
Summary
  • Symbol
    Dppa2
  • Name
    developmental pluripotency associated 2
  • Synonyms
    2410088E07Rik, ECAT15-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2157523
    NCBI Gene: 73703
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:48130637-48139876 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 30.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    362 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2157523
 protein coding gene Chr16:48124271-48140086 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022864
 protein coding gene Chr16:47161865-47175097 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0022802
 protein coding gene Chr16:46589143-46598730 (+)
BALB/cJ MGP_BALBcJ_G0022831
 protein coding gene Chr16:45129792-45143132 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0023278
 protein coding gene Chr16:48330129-48345461 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020791
 protein coding gene Chr16:45237168-45247391 (+)
CAST/EiJ MGP_CASTEiJ_G0022120
 protein coding gene Chr16:46922648-46932104 (+)
CBA/J MGP_CBAJ_G0022567
 protein coding gene Chr16:50231435-50247358 (+)
DBA/2J MGP_DBA2J_G0022698
 protein coding gene Chr16:44803275-44812773 (+)
FVB/NJ MGP_FVBNJ_G0022674
 protein coding gene Chr16:44687544-44697677 (+)
LP/J MGP_LPJ_G0022766
 protein coding gene Chr16:46915394-46930061 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022692
 protein coding gene Chr16:49925912-49941453 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023293
 protein coding gene Chr16:46580459-46589660 (+)
PWK/PhJ MGP_PWKPhJ_G0021860
 protein coding gene Chr16:45154294-45165288 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021690
 protein coding gene Chr16:46478770-46490598 (+)
WSB/EiJ MGP_WSBEiJ_G0022165
 protein coding gene Chr16:46635081-46645309 (+)



Homology
more
  • Human Ortholog
    DPPA2, developmental pluripotency associated 2
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPPA2, developmental pluripotency associated 2
  • Synonyms
    CT100, ECAT15-2, PESCRG1
  • Links
    NCBI Gene ID: 151871
    neXtProt AC: NX_Q7Z7J5
    UniProt: Q7Z7J5

  • Chr Location
    3q13.13
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 1 genetic background
    16 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele do not survive to weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    38
  • cDNA Data
    44
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 73703 NCBI Gene Model | MGI Sequence Detail 9240 C57BL/6J ±  kb
transcript NM_028615 RefSeq | MGI Sequence Detail 1941 Not Specified  
polypeptide Q9CWH0 UniProt | EBI | MGI Sequence Detail 301 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006665 developmental pluripotency-associated protein 2
    (term hierarchy)
  • InterPro Domains
    IPR039590 Developmental pluripotency-associated protein 2/4
    IPR025892 Developmental pluripotency-associated protein 2/4, central domain
    IPR025891 Developmental pluripotency-associated protein 2/4, C-terminal domain
Molecular
Reagents
less
  • All nucleic 47
    cDNA 44
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGI:1920953
References
more
  • Summaries
    All 44
    Developmental Gene Expression 10
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:316936 Kubinyecz O, et al., Maternal Dppa2 and Dppa4 are dispensable for zygotic genome activation but important for offspring survival. Development. 2021 Dec 15;148(24):dev200191
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory