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Idh3b Gene Detail
Summary
  • Symbol
    Idh3b
  • Name
    isocitrate dehydrogenase 3 (NAD+) beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158650
    NCBI Gene: 170718
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:130121229-130126371 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.20 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158650
 protein coding gene Chr2:130121229-130126467 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026498
 protein coding gene Chr2:133728051-133733283 (-)
A/J MGP_AJ_G0026462
 protein coding gene Chr2:128318226-128323463 (-)
AKR/J MGP_AKRJ_G0026437
 protein coding gene Chr2:132001485-132006717 (-)
BALB/cJ MGP_BALBcJ_G0026474
 protein coding gene Chr2:128675553-128680763 (-)
C3H/HeJ MGP_C3HHeJ_G0026217
 protein coding gene Chr2:132453571-132458788 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026919
 protein coding gene Chr2:137869465-137874709 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024296
 protein coding gene Chr2:123062403-123067585 (-)
CAST/EiJ MGP_CASTEiJ_G0025678
 protein coding gene Chr2:132704061-132709245 (-)
CBA/J MGP_CBAJ_G0026197
 protein coding gene Chr2:142976346-142981563 (-)
DBA/2J MGP_DBA2J_G0026331
 protein coding gene Chr2:127706203-127711765 (-)
FVB/NJ MGP_FVBNJ_G0026295
 protein coding gene Chr2:126328426-126333643 (-)
LP/J MGP_LPJ_G0026436
 protein coding gene Chr2:133992537-133997828 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026315
 protein coding gene Chr2:146827982-146833230 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026974
 protein coding gene Chr2:131972504-131978805 (-)
PWK/PhJ MGP_PWKPhJ_G0025414
 protein coding gene Chr2:127260514-127265708 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025216
 protein coding gene Chr2:131090858-131096060 (-)
WSB/EiJ MGP_WSBEiJ_G0025752
 protein coding gene Chr2:132897443-132904099 (-)



Homology
more
  • Human Ortholog
    IDH3B, isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IDH3B, isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta
  • Synonyms
    RP46
  • Links
    NCBI Gene ID: 3420
    neXtProt AC: NX_O43837
    UniProt: O43837

  • Chr Location
    20p13; chr20:2658395-2664219 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IDH3B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout does not cause eye phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    830
  • Tissues
    100
  • cDNA Data
    8
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 170718 NCBI Gene Model | MGI Sequence Detail 5143 C57BL/6J ±  kb
    transcript NM_130884 RefSeq | MGI Sequence Detail 1520 C57BL/6  
    polypeptide NP_570954 RefSeq | MGI Sequence Detail 384 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008890 isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR004434 Isocitrate dehydrogenase NAD-dependent
      IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site
      IPR024084 Isopropylmalate dehydrogenase-like domain
    • GlyGen
      Q91VA7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2139470
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory