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Acot2 Gene Detail
Summary
  • Symbol
    Acot2
  • Name
    acyl-CoA thioesterase 2
  • Synonyms
    Mte1, MTE-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:2159605
    NCBI Gene: 171210
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:84034635-84040647 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 38.99 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    311 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2159605
 protein coding gene Chr12:84034635-84040651 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019922
 protein coding gene Chr12:84679698-84688635 (+)
A/J MGP_AJ_G0019879
 protein coding gene Chr12:81445869-81454660 (+)
AKR/J MGP_AKRJ_G0019855
 protein coding gene Chr12:83655594-83661873 (+)
BALB/cJ MGP_BALBcJ_G0019859
 protein coding gene Chr12:81789028-81795497 (+)
C3H/HeJ MGP_C3HHeJ_G0019665
 protein coding gene Chr12:84115204-84125336 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020311
 protein coding gene Chr12:87108649-87124941 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017929
 protein coding gene Chr12:78391412-78399562 (+)
CAST/EiJ MGP_CASTEiJ_G0019215
 protein coding gene Chr12:79058850-79065233 (+)
CBA/J MGP_CBAJ_G0019636
 protein coding gene Chr12:90413153-90426636 (+)
DBA/2J MGP_DBA2J_G0019751
 protein coding gene Chr12:80990770-80997485 (+)
FVB/NJ MGP_FVBNJ_G0019737
 protein coding gene Chr12:79965772-79974854 (+)
LP/J MGP_LPJ_G0019823
 protein coding gene Chr12:84561357-84569584 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019776
 protein coding gene Chr12:93391855-93399582 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020345
 protein coding gene Chr12:83245691-83254360 (+)
PWK/PhJ MGP_PWKPhJ_G0018978
 protein coding gene Chr12:75471663-75479728 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018773
 protein coding gene Chr12:77729285-77736565 (+)
WSB/EiJ MGP_WSBEiJ_G0019267
 protein coding gene Chr12:83927625-83932880 (+)



Homology
more
  • Human Ortholog
    ACOT2, acyl-CoA thioesterase 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACOT2, acyl-CoA thioesterase 2
  • Synonyms
    CTE1A, CTE-IA, MTE1, PTE2, PTE2A, ZAP128
  • Links
    NCBI Gene ID: 10965
    neXtProt AC: NX_P49753
    UniProt: P49753

  • Chr Location
    14q24.3; chr14:73567620-73575658 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    96
  • cDNA Data
    19
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021226 Ensembl Gene Model | MGI Sequence Detail 6013 C57BL/6J ±  kb
transcript ENSMUST00000021649 Ensembl | MGI Sequence Detail 2196 Not Applicable  
polypeptide ENSMUSP00000021649 Ensembl | MGI Sequence Detail 453 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000003636 acyl-coenzyme A thioesterase 2, mitochondrial
    (term hierarchy)
  • EC
    3.1.2.2
  • InterPro Domains
    IPR016662 Acyl-CoA thioesterase, long chain
    IPR042490 Acyl-CoA thioester hydrolase/BAAT, N-terminal
    IPR006862 Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
    IPR029058 Alpha/Beta hydrolase fold
    IPR014940 BAAT/Acyl-CoA thioester hydrolase C-terminal
  • GlyGen
    Q9QYR9 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 21
    cDNA 19
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:3035001
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:59046 Hunt MC, et al., Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. J Biol Chem. 1999 Nov 26;274(48):34317-26
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory