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H1f8 Gene Detail
Summary
  • Symbol
    H1f8
  • Name
    H1.8 linker histone
  • Synonyms
    H1-8, H1foo, H1oo
  • Feature Type
    protein coding gene
  • IDs
    MGI:2176207
    NCBI Gene: 171506
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:115921899-115927197 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 53.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    307 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2176207
 protein coding gene Chr6:115921892-115927203 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031160
 protein coding gene Chr6:118591970-118597235 (+)
A/J MGP_AJ_G0031130
 protein coding gene Chr6:114041420-114046710 (+)
AKR/J MGP_AKRJ_G0031060
 protein coding gene Chr6:117093309-117098766 (+)
BALB/cJ MGP_BALBcJ_G0031140
 protein coding gene Chr6:113846581-113851879 (+)
C3H/HeJ MGP_C3HHeJ_G0030568
 protein coding gene Chr6:67198686-67207330 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031599
 protein coding gene Chr6:121612936-121618263 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028763
 protein coding gene Chr6:111039367-111044677 (+)
CAST/EiJ MGP_CASTEiJ_G0030247
 protein coding gene Chr6:117469177-117474472 (+)
CBA/J MGP_CBAJ_G0030826
 protein coding gene Chr6:126382839-126388265 (+)
DBA/2J MGP_DBA2J_G0030980
 protein coding gene Chr6:112957657-112962922 (+)
FVB/NJ MGP_FVBNJ_G0030933
 protein coding gene Chr6:112137300-112142602 (+)
LP/J MGP_LPJ_G0031059
 protein coding gene Chr6:118596095-118601364 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030968
 protein coding gene Chr6:130546382-130551646 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031627
 protein coding gene Chr6:117119211-117124480 (+)
PWK/PhJ MGP_PWKPhJ_G0029963
 protein coding gene Chr6:111974290-111979948 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029791
 protein coding gene Chr6:115845408-115850685 (+)
WSB/EiJ MGP_WSBEiJ_G0030331
 protein coding gene Chr6:117384090-117389408 (+)



Homology
more
  • Human Ortholog
    H1-8, H1.8 linker histone
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H1-8, H1.8 linker histone
  • Synonyms
    H1.8, H1FOO, H1oo, osH1
  • Links
    NCBI Gene ID: 132243
    neXtProt AC: NX_Q8IZA3
    UniProt: Q8IZA3

  • Chr Location
    3q22.1; chr3:129543175-129551467 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit no detectable abnormalities. Oocytes develop normally and no defects in fertility or litter sizes are observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    29
  • cDNA Data
    52
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042279 Ensembl Gene Model | MGI Sequence Detail 5299 C57BL/6J ±  kb
    transcript ENSMUST00000037831 Ensembl | MGI Sequence Detail 1113 Not Applicable  
    polypeptide ENSMUSP00000036951 Ensembl | MGI Sequence Detail 304 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 52
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141780, MGI:6325026
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 12
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory